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Pragmatic trial of pharmacogenetic testing at the time of prescription for a selective serotonin reuptake inhibitor, tricyclic antidepressant or atypical antipsychotic. Does real time intervention improve patient outcomes?
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | No Intervention | ||
| Intervention | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pharmacogenetic testing | Diagnostic Test | Basic pharmacogenetic panel |
|
| Measure | Description | Time Frame |
|---|---|---|
| Patient oriented outcome1- Clinical Improvement | Clinically significant improvement as noted by physician (Subjective and PHQ-9) | 6 months |
| Patient oriented outcome2- Adverse effects | Number of patients with specific, common side effects (from medical chart) | 6 months |
| Patient oriented outcome3- Time to Improvement | Days to clinical improvement (from medical chart) | Up to 6 months |
| Patient oriented outcome5- Visits | Total number of visits to clinic with medication titration required (from medical chart) | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D003863 | Depression |
| D009771 | Obsessive-Compulsive Disorder |
| D000098647 | Generalized Anxiety Disorder |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
| D001008 | Anxiety Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000071185 | Pharmacogenomic Testing |
| ID | Term |
|---|---|
| D005820 | Genetic Testing |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| D008919 | Investigative Techniques |
| D005821 | Genetic Techniques |
| D033142 | Genetic Services |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
| D003954 | Diagnostic Services |
| D011314 | Preventive Health Services |