HLA-mismatched Microtransplantation Without Immunosuppressive Treatment in Patients With Myeloid Hemopathies

HLA-mismatched Microtransplantation Without Immunosuppressive Treatment in Patients With Myeloid Hemopathies

This study aims at evaluating the safety of an approach based on HLA-mismatched Microtransplantation without immunosuppressive treatment in patients With myeloid hemopathies who are ineligible to conventional allograft

Inclusion Criteria:

• Age> or = 65 years with a myeloid hemopathy in Complete Remission or Complete remission with incomplete hematological recovery or Age<65 years with an ineligibility to allograft (contraindication to conditioning)
• HLA-partially matched family donors
• Affiliated to(or beneficiary of) the Social Security
• Informed consent signed

Exclusion Criteria:

• AML3
• Previous Hematopoietic Stem Cell TRansplantation
• Uncontrolled infection -PS>3 -Other progressive cancer
• Psychiatric disease
• Vulnerable person or unable to provide informed consent
• Emergency
• Unable to comply with required study follow up