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This study investigates the effects of Canderel, an aspartame and acesulfame-k blend artificial sweetener powder, on post-postprandial blood glucose levels and appetite scores.
The study is separated into two parts: A) investigating the effects of artificial sweeteners in combination with complex carbohydrates; and B) investigating the effects of artificial sweeteners in combination with simple sugars.
A) Participants will be randomly given either the placebo drink (3g of maltodextrin dissolved in 250ml of water) or the Canderel drink (3g of Canderel dissolved in 250ml of water) alongside an isocaloric high carbohydrate breakfast. Blood glucose measurements will be obtained through finger pricking and appetite will be measured using self-reported visual analog scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after breakfast.
B)Participants will be randomly given either the placebo drink (3g of Lyle's Golden syrup and 3g of maltodextrin dissolved in 250ml of water) or the Canderel+sugars drink (3g of Canderel and 3g of Lyle's Golden syrup dissolved in 250ml of water) . Blood glucose measurements will be obtained through finger pricking and appetite will be measured using self-reported visual analog scores rating hunger, desire to eat, fullness and alertness for up to 3 hours after drink
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experiment A- experimental | Experimental | 3g Canderel in 250ml water |
|
| Experiment A- control | No Intervention | 3g of maltodextrin in 250 ml of water | |
| Experiment B- experimental | Experimental | 3g Canderel + 35g Lyle's Golden Syrup in 250 ml water |
|
| Experiment B- control | No Intervention | 3g Lyle's Golden Syrup + 35g of maltodextrin in 250 ml of water |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Canderel drink | Dietary Supplement | 1.4% aspartame and 0.95% acesulfame-k and 95% maltodextrin; 3g dissolved in 250ml of water |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Blood glucose | Capillary blood obtained from fingerprick and measured using glucose monitor | 0-180min (Measured from baseline to 90min every 15min; 90-180min every 30min) |
| Change in Appetite | Feelings of hunger, desire to eat, fullness and alertness measured using Visual Analog Scale (VAS) | 0-180min (Measured from baseline to 90min every 15min; 90-180min every 30min) |
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Inclusion Criteria:
Exclusion Criteria:
-
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| Name | Affiliation | Role |
|---|---|---|
| Dr. Christopher Corpe | King's College London | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| King's College London | London | SE1 9NH | United Kingdom |
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| ID | Term |
|---|---|
| D001070 | Appetitive Behavior |
| D044882 | Glucose Metabolism Disorders |
| ID | Term |
|---|---|
| D001522 | Behavior, Animal |
| D001519 | Behavior |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Canderel+Lyle's Golden Syrup drink | Dietary Supplement | Canderel: 1.4% aspartame and 0.95% acesulfame-k and 95% maltodextrin; 3g dissolved in 250ml of water Lyle's Golden Syrup: 35 g (27g of glucose and fructose) |
|