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Difficult venous access in some patients such as those with obesity, IV drug use, chronic illness, or vascular pathology often causes increased discomfort and delayed patient care due to multiple attempts to gain venous access. If access is achieved at all, it usually results in a much smaller catheter than needed to provide optimal care for the patient. Ultrasound-guided placement of a peripheral IV in the internal jugular vein is common in the investigators' emergency department and is gaining popularity across the US. This study investigates the utility and safety of placing an ultrasound-guided peripheral IV catheter in the internal jugular vein.
Intravenous access in the emergency department (ED) patient is essential for medication delivery, IV fluid resuscitation, rapid serum laboratory diagnostics, and administration of IV contrast for CT scans. Some patients, such as those with obesity, IV drug abuse, chronic illnesses, or vascular pathology may have difficult IV access. These patients are problematic for the busy ED nurse and physician as this can lead to a time consuming process, which slows efficiency and patient care.
Previously, patients with difficult IV access often required central venous catheterization, a procedure that can result in a number of serious complications (1). More recently, ultrasound guidance has been touted as an effective means to achieve peripheral IV access on these patients (2). In one study (2), there was a 73% first attempt cannulation rate, which seems respectable, but not excellent. Additionally, 8% of the successful IVs failed within one hour (2). Another study compared ultrasonographically guided peripheral IVs to non-ultrasonographically guided IVs, and it found that using ultrasound did not decrease the amount of time or the number of attempts it took to successfully place a peripheral IV (3). Although ultrasound-guided peripheral IV's have a role, there remains room for improvement in being able to achieve rapid IV access in those patients who need IV access on an urgent basis.
It seems that we still have room to improve our ability to obtain difficult IV access, and a relatively new technique may be the answer. Ultrasound guided IVs are typically attempted in the upper extremities, targeting the brachial or basilic veins, but a recently described technique --- the "peripheral IJ" --- involves placement of a peripheral IV catheter in the internal jugular vein (4,5).
The peripheral IJ is gaining popularity in the investigators' ED as a solution to the difficult vascular access patient. In the investigators' clinical experience, it is a quick and easy procedure that is also safe, tolerated well by patients, and requires few resources. Several small studies have concluded that this is a fast and safe procedure and a feasible alternative to central access in the difficult vascular access patient (4-7). These studies mention the theoretical risks as being similar to central venous access such as carotid artery puncture, hematoma, pneumothorax, and line infection, however none of these have actually been reported (4-7). Therefore, we seek primarily to determine the average number of attempts to cannulation for ultrasound-guided peripheral IJ placement. Secondarily, we wish to determine: 1) the prevalence of potential complications related to this procedure 2) the average time it takes the emergency physician to complete the procedure 3) the patient's satisfaction with the procedure. We will compare the data from this study to the published data for other types of ultrasound-guided peripheral IVs.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| US guided IJ | Experimental | A physician placed ultrasound-guided IV in the internal jugular vein |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| US guided IJ | Procedure | IV catheter placement |
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| Measure | Description | Time Frame |
|---|---|---|
| Number of Participants With Successful Cannulation of the Internal Jugular Vein | The primary study endpoint is successful cannulation vs failure to cannulate the internal jugular vein. | Less than 20 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Prevalence of Complications Related to Cannulation of the Internal Jugular Vein. | Percentage of Participants with successfully placed lines with a complication | 24 hours |
| The Median Time Required for Cannulation of the Internal Jugular Vein by an Emergency Physician. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Joseph A Zitek, MD | UMCSN | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Medical Center of Southen Nevada | Las Vegas | Nevada | 89102 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26557487 | Background | Kornbau C, Lee KC, Hughes GD, Firstenberg MS. Central line complications. Int J Crit Illn Inj Sci. 2015 Jul-Sep;5(3):170-8. doi: 10.4103/2229-5151.164940. | |
| 10577399 | Background | Keyes LE, Frazee BW, Snoey ER, Simon BC, Christy D. Ultrasound-guided brachial and basilic vein cannulation in emergency department patients with difficult intravenous access. Ann Emerg Med. 1999 Dec;34(6):711-4. doi: 10.1016/s0196-0644(99)70095-8. |
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| ID | Title | Description |
|---|---|---|
| FG000 | US Guided IJ | A physician placed ultrasound-guided IV in the internal jugular vein US guided IJ: IV catheter placement Ultrasound: Ultrasound-guided Internal Jugular vein |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | US Guided IJ | A physician placed ultrasound-guided IV in the internal jugular vein US guided IJ: IV catheter placement Ultrasound: Ultrasound-guided Internal Jugular vein |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Number of Participants With Successful Cannulation of the Internal Jugular Vein | The primary study endpoint is successful cannulation vs failure to cannulate the internal jugular vein. | Posted | Count of Participants | Participants | Less than 20 minutes |
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We monitored for adverse events throughout the patient's hospitalization, the length of which ranged from a few hours to a maximum of 2 weeks.
The adverse events that we tracked included local hematoma, pneumothorax, arterial puncture, bacteremia/line infection, and line thrombus. Trained research assistants watched line placement to assess for these complications. They also rechecked the line 1 hour after placement, and then once every 24 hours until the line was removed. They also checked the results of CXRs to look for pneumothoraces, and they checked blood cultures results.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | US Guided IJ | A physician placed ultrasound-guided IV in the internal jugular vein US guided IJ: IV catheter placement Ultrasound: Ultrasound-guided Internal Jugular vein |
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| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Complications from IV line placement | Vascular disorders | Systematic Assessment | The only complication found was a local hematoma. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Zitek | University Medical Center of Southern Nevada | 702-383-7885 | zitek10@gmail.com |
| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot | Yes | No | No | Study Protocol | Apr 1, 2017 | Jan 10, 2019 | Prot_000.pdf |
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| ID | Term |
|---|---|
| D014463 | Ultrasonography |
| ID | Term |
|---|---|
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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This study utilizes a convenience sample of patient who have difficult venous access with at least 2 attempts by nursing to achieve venous access. The patient will be consented and a physician placed ultrasound-guided peripheral IV will be placed in the internal jugular vein.
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| Ultrasound | Device | Ultrasound-guided Internal Jugular vein |
|
The median time it took an Emergency Physician from needle puncture to cannulation in minutes |
| Less than 20 minutes |
| 18824276 | Background | Stein J, George B, River G, Hebig A, McDermott D. Ultrasonographically guided peripheral intravenous cannulation in emergency department patients with difficult intravenous access: a randomized trial. Ann Emerg Med. 2009 Jul;54(1):33-40. doi: 10.1016/j.annemergmed.2008.07.048. Epub 2008 Sep 27. |
| 22579025 | Background | Teismann NA, Knight RS, Rehrer M, Shah S, Nagdev A, Stone M. The ultrasound-guided "peripheral IJ": internal jugular vein catheterization using a standard intravenous catheter. J Emerg Med. 2013 Jan;44(1):150-4. doi: 10.1016/j.jemermed.2012.02.044. Epub 2012 May 11. |
| 26469683 | Background | Butterfield M, Abdelghani R, Mohamad M, Limsuwat C, Kheir F. Using Ultrasound-Guided Peripheral Catheterization of the Internal Jugular Vein in Patients With Difficult Peripheral Access. Am J Ther. 2017 Nov/Dec;24(6):e667-e669. doi: 10.1097/MJT.0000000000000357. |
| 26776533 | Background | Kiefer D, Keller SM, Weekes A. Prospective evaluation of ultrasound-guided short catheter placement in internal jugular veins of difficult venous access patients. Am J Emerg Med. 2016 Mar;34(3):578-81. doi: 10.1016/j.ajem.2015.11.069. Epub 2015 Dec 4. |
| 22033389 | Background | Zwank MD. Ultrasound-guided catheter-over-needle internal jugular vein catheterization. Am J Emerg Med. 2012 Feb;30(2):372-3. doi: 10.1016/j.ajem.2011.08.013. Epub 2011 Oct 26. No abstract available. |
| 26823937 | Background | Ash AJ, Raio C. Seldinger Technique for Placement of "Peripheral" Internal Jugular Line: Novel Approach for Emergent Vascular Access. West J Emerg Med. 2016 Jan;17(1):81-3. doi: 10.5811/westjem.2015.11.28726. Epub 2016 Jan 12. |
| years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Race/Ethnicity, Customized | Count of Participants | Participants |
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| Region of Enrollment | Count of Participants | Participants |
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| Secondary | Prevalence of Complications Related to Cannulation of the Internal Jugular Vein. | Percentage of Participants with successfully placed lines with a complication | Posted | Count of Participants | Participants | 24 hours |
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| Secondary | The Median Time Required for Cannulation of the Internal Jugular Vein by an Emergency Physician. | The median time it took an Emergency Physician from needle puncture to cannulation in minutes | Posted | Median | Inter-Quartile Range | minutes | Less than 20 minutes |
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| 0 |
| 35 |
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| 35 |
| 1 |
| 35 |
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