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The present study is to demonstrate the effect of the presence of bacterial translocation detected by bacterial deoxyribonucleic acid (bactDNA) in blood and ascites using the polymerase chain reaction (PCR) on some haemodynamic and coagulation parameters during a liver transplant procedure.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| DNA positive patients | patients who have bacterial DNA in their samples |
| |
| DNA negative patients | patients who do not have bacterial DNA in their samples |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PCR for bacterial translocation | Diagnostic Test | samples taken from the blood and ascites of patients to search for bacterial DNA |
|
| Measure | Description | Time Frame |
|---|---|---|
| change in the mean arterial blood pressure | at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase | |
| antifactor X activity | at the beginning of surgery | |
| change in the heart rate | at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase | |
| change in the cardiac output | at the beginning of surgery then 15 nim after dissection then 15 min after the anhepatic phase then 15 min at the reperfusion phase |
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Inclusion Criteria:
• patients with liver failure undergoing liver transplantation
Exclusion Criteria:
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adult patients with grade C liver cirrhosis with liver failure undergoing liver transplantation
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| Name | Affiliation | Role |
|---|---|---|
| ahmed mukhtar, MD | Cairo University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Elmoasah Hospital | Alexandria | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29699477 | Derived | Moharem HA, Fetouh FA, Darwish HM, Ghaith D, Elayashy M, Hussein A, Elsayed R, Khalil MM, Abdelaal A, ElMeteini M, Mukhtar A. Effects of bacterial translocation on hemodynamic and coagulation parameters during living-donor liver transplant. BMC Anesthesiol. 2018 Apr 25;18(1):46. doi: 10.1186/s12871-018-0507-7. |
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| ID | Term |
|---|---|
| D018988 | Bacterial Translocation |
| ID | Term |
|---|---|
| D018407 | Bacterial Physiological Phenomena |
| D008827 | Microbiological Phenomena |
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