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| Name | Class |
|---|---|
| Longhua Hospital | OTHER |
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Investigators aimed to evaluate the clinical efficacy of integrated traditional Chinese and Western medicine in the treatment of asthma, and to further optimize the prescription of Chinese medicine treatment.
The incidence of asthma in China is high and the rate of control is low. Traditional Chinese medicine has a long history of treating asthma, and has a good clinical curative effect.The purpose of this study is to evaluate the clinical efficacy of traditional Chinese medicine in the treatment of asthma, and to further optimize the prescription of Chinese medicine treatment.
In this study, investigators recruited chronic persistent asthma participants, and gave the corresponding western medicine background treatment and traditional Chinese medicine treatment program for 28 days.Participants will undergo a physical examination, lung function, blood and sputum collection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hanxiao treatment group | Experimental | 80 patients belongs to Hanxiao type of asthma will take Ke Chuan Liu Wei Granule oral therapy twice everyday for 28 days and receive background therapy of ICS and beta2-agonist. |
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| Hanxiao control group | Sham Comparator | 80 patients belongs to Hanxiao type of asthma will take Ke Chuan Liu Wei Granule placebo oral therapy twice everyday for 28 days and receive background therapy of ICS and beta2-agonist. |
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| Xuxiao treatment group | Experimental | 80 patients of deficiency type of asthma will take Yang He Ping Chuan Granule oral therapy thrice everyday for 28 days and background therapy of ICS and beta2-agonist. |
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| Xuxiao control group | Sham Comparator | 80 patients of deficiency type of asthma will take Yang He Ping Chuan Granule placebo oral therapy thrice everyday for 28 days and background therapy of ICS and beta2-agonist. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ke Chuan Liu Wei Granule | Drug | Traditional Chinese Medicine |
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| Measure | Description | Time Frame |
|---|---|---|
| Asthma control rate change | Measured the change from Baseline of asthma control rate | up to 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Lung function(FEV1, PEF) | Measured routine pulmonary ventilation function test | Up to 4 weeks |
| FeNO | The fractional concentration of exhaled nitric oxide |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Zifeng Ma, Doctor | Contact | +8621-64385700 | 1307 | mzf05@126.com |
| Zhenghui Lu, PHD | Contact | +8621-64385700 | 1307 | tcmdoctorlu@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Huiyong Zhang, Director | tcmdoctorzhang@163.com | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Fenglin Street Community Health Service Center | Recruiting | Shanghai | Shanghai Municipality | 200030 | China |
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| ID | Term |
|---|---|
| D001249 | Asthma |
| ID | Term |
|---|---|
| D001982 | Bronchial Diseases |
| D012140 | Respiratory Tract Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
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All treatment group received traditional chinese medicine plus a standard anti-asthma treatment on study entry, and the control group received placebo and standard anti-asthma treatment.
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Double-blind trial
| Yang He Ping Chuan Granule | Drug | Traditional Chinese Medicine |
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| Ke Chuan Liu Wei Granule placebo | Other | Placebo |
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| Yang He Ping Chuan Granule placebo | Other | Placebo |
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| Up to 4 weeks |
| Blood routine examination | Hematological routine examination | Up to 4 weeks |
| Liver function test | Simple liver function test | Up to 4 weeks |
| Cytokine levels of induced sputum | Measured cytokine levels of induced sputum supernatant | Up to 4 weeks |
| Kidney function test | Simple kidney function test | Up to 4 weeks |
| Kangjian Street Community Health Service Center | Not yet recruiting | Shanghai | Shanghai Municipality | 200030 | China |
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| Tianping Street Community Health Service Center | Not yet recruiting | Shanghai | Shanghai Municipality | 200030 | China |
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| Longhua Hospital Affiliated Shanghai University of TCM | Recruiting | Shanghai | Shanghai Municipality | 200032 | China |
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| Fengxian District Hospital of TCM | Recruiting | Shanghai | Shanghai Municipality | 201400 | China |
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| D012130 |
| Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |