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Depression is common in Parkinson's disease (PD), but the effective treatment is not established yet. tDCS is a non-invasive brain stimulation to modulate brain function. The tDCS on the depression in general population were already conducted, but not in PD. This study is to know whether transcranial direct current stimulation (tDCS) is effective for the treatment of depression in PD. Participant will be asked to visit three consecutive days for the non-invasive stimulation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Real tDCS | Active Comparator |
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| Sham tDCS | Sham Comparator |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial direct current stimulation (tDCS) | Device | tDCS is one of non-invasive brain stimulation. Constant, low current is delivered to the specific brain areas to change brain plasticity. |
| Measure | Description | Time Frame |
|---|---|---|
| BDI score | The changes of Beck depression inventory after tDCS | (1) before the1st visit (within one month) (2) right after the 3rd tDCS (3) within one months after the 3rd tDCS |
| Measure | Description | Time Frame |
|---|---|---|
| HDRS score | The changes of Hamilton Depression Rating Scale after tDCS | (1) before the 1st visit (within one month) (2) right after 3rd tDCS, within 24 hours (3) within one months after the 3rd tDCS |
| MADRS score |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sang Jin Kim, MD, PhD | Contact | 82-51-890-8954 | jsk120@hanmail.net |
| Name | Affiliation | Role |
|---|---|---|
| Sang Jin Kim, MD, PhD | Inje University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Inje university, Busan Paik Hospital | Recruiting | Busan | South Korea |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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Randomized, Parallel, Sham-controlled, single-blinded study
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The changes of Mongomery-Asberg Depression Rating Scale after tDCS
| (1) before the 1st visit (within one month) (2) right after the 3rd tDCS, within 24 hours (3) within one months after 3rd tDCS |
| resting state functional MRI | The changes of resting state functional MRI after tDCS | (1) before the 1st visit (within one month) (2) after the 3rd tDCS, within 24 hours (on the same day as the 3rd tDCS) |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |