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| Name | Class |
|---|---|
| Philips GmbH, Innovative Technologies, Aachen | UNKNOWN |
| Klinik für Unfall - und Handchirurgie, Universitätsklinikum Düsseldorf | UNKNOWN |
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Ultraviolet light exposure was shown to be able to release nitric oxide from the skin into the blood stream and lead to an acute decrease in blood pressure and increase in vascular function. Additionally, preliminary work indicates that UV free blue light also releases nitric oxide in the skin mediating similar effects as seen with ultraviolet light A(UVA). It is the goal of the present experimental study to investigate the hemodynamic effects of whole body blue light exposure including blood pressure, endothelial function and vascular stiffness. Therefore, healthy volunteers will be exposed to 30 minutes whole body blue light (453 nm wavelength) and the change in blood pressure and endothelial function (Flow mediated dilation (FMD)), heart rate, forearm-blood flow, forearm vascular resistance central blood pressure and vascular stiffness ( pulse wave analysis by sphygmocor) will be measured.
In this randomized controlled cross-over study, 20 healthy subjects aged 30 to 60 years will participate.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Blue light | Experimental | Each subject will be undergo a whole body exposure to blue light (453 nm wavelength) for 30 minutes. |
|
| Control exposure | Placebo Comparator | Each participant will also undergo a control examination, where the body will be covered with a light tight foil during blue light exposure for 30 minutes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blue light | Procedure | Subjects will be exposed to blue light (453 nm wavelength) for 30 minutes |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of peripheral blood pressure | Change of peripheral blood pressure as measured before, during and up to 2 hours after 30 min blue light as compared to control | baseline, during 30 min exposure and 2 hours thereafter |
| Measure | Description | Time Frame |
|---|---|---|
| Change in endothelial function | measured by flow mediated dilation (FMD) before, immediately after 30 min exposure and at 2 h thereafter | baseline, during 30 min exposure and 2 hours thereafter |
| Change from baseline heart rate |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Christian Heiß, MD | Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Dusseldorf | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Division of Cardiology, Pulmonary Disease and Vascular Medicine | Düsseldorf | North Rhine-Westphalia | 40225 | Germany |
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| ID | Term |
|---|---|
| D000095743 | Blue Light |
| ID | Term |
|---|---|
| D008027 | Light |
| D060733 | Electromagnetic Radiation |
| D055590 | Electromagnetic Phenomena |
| D060328 | Magnetic Phenomena |
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| control exposure | Procedure | Subjects will get control exposure to 30 minutes of whole body, which causes only comparable warming of skin as with blue light exposure. |
|
measured by electrocardiography (ECG) before, during and up to 2 hours after 30 min blue light as compared to control
| baseline, during 30 min exposure and 2 hours thereafter |
| Change from baseline forearm blood flow | measured by ultrasound before, immediately after 30 min exposure and at 2 h thereafter | baseline, during 30 min exposure and 2 hours thereafter |
| Change from baseline forearm vascular resistance | measured by ultrasound before, immediately after 30 min exposure and at 2 h thereafter | baseline, during 30 min exposure and 2 hours thereafter |
| Change from baseline central blood pressure | measured by applanation tonometry before, immediately after 30 min exposure and at 2 h thereafter | baseline, during 30 min exposure and 2 hours thereafter |
| Change from baseline vascular stiffness | measured by applanation tonometry before, immediately after 30 min exposure and at 2 h thereafter | baseline, during 30 min exposure and 2 hours thereafter |
| Change from baseline NO-species | determined by chemiluminescence before, immediately after 30 min exposure and at 2 h thereafter | baseline, during 30 min exposure and 2 hours thereafter |
| Change from baseline Cortisol | measured before, immediately after 30 min exposure and at 2 h thereafter | baseline, during 30 min exposure and 2 hours thereafter |
| Change from baseline Endorphins | measured before, immediately after 30 min exposure and at 2 h thereafter | baseline, during 30 min exposure and 2 hours thereafter |
| D055585 |
| Physical Phenomena |
| D055620 | Optical Phenomena |
| D011827 | Radiation |
| D011840 | Radiation, Nonionizing |