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| Name | Class |
|---|---|
| Institute of Anatomy TU Dresden | UNKNOWN |
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PURPOSE: To report clinical and histochemical results of oral mucosa graft transplantation in eyes with limbal stem cell deficiency.
DESIGN: Prospective observational study.
METHODS: 32 eyes of 27 patients with limbal stem cell deficiency underwent direct oral mucosa graft transplantation with amniotic membrane transplantation with a mean follow-up of 19 months. Clinical course of the disease including emergency surgeries, planned curative procedures, conjunctival inflammation, acute inpatient treatment and best corrected visual acuity were assessed at 3 months postoperatively and at last follow up visit. The unneeded parts of oral mucosa graft were analyzed immunohistochemically with staining for mesenchymal stem cell markers and pericytes (CD 90, CD 146, CD 166, CD 31, CD 68, protein gene product).
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| Measure | Description | Time Frame |
|---|---|---|
| change in number of acute surgeries | baseline, 3 months after oral mucosa transplantation; through study completion, an average of 19 months | |
| change in days of acute inpatient treatment | baseline, 3 months after oral mucosa transplantation; through study completion, an average of 19 months |
| Measure | Description | Time Frame |
|---|---|---|
| change in number of curative surgical procedures after oral mucosa transplantation | baseline, 3 months after oral mucosa transplantation; through study completion, an average of 19 months | |
| change in conjunctival inflammation | baseline, 3 months after oral mucosa transplantation; through study completion, an average of 19 months |
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Inclusion Criteria:
Exclusion Criteria:
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All patients treated with oral mucosa with amniotic membrane transplantation in Klinikum Chemnitz 2015-2017
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| Name | Affiliation | Role |
|---|---|---|
| Katrin Engelmann, PhD | Klinikum Chemnitz | Principal Investigator |
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| ID | Term |
|---|---|
| D000092423 | Limbal Stem Cell Deficiency |
| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| D005128 | Eye Diseases |
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oral mucosa tissue