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The aim of this study was to assess the vitamin D status and analyze risk factors for vitamin D inadequacy of Chinese children and adolescents aged 6-17y.
In this study, we analyzed the vitamin D status of Chinese children and adolescents aged 6-17y, and related risk factors (such as gender, region strata, ambient UVB level at area of residence, season, and outdoor time, etc.). Serum 25 hydroxyvitamin D [25(OH)D] was measured with a radioimmunoassay kit in 15 000 children and adolescent participants in Chinese national nutrition and health survey (CNNHS) 2010-2012. Age, gender, region type, ethnicity, outdoor time, vitamin D supplementation were recorded in unified design questionnaires. Season was recorded by the date of blood taken; location was divided into north and south by China's Qinling mountains and Huaihe river; and ambient ultraviolet B (UVB) radiation level was classified according to the corresponding dose of each participant living area from National Aeronautics and Space Administration data.
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| Measure | Description | Time Frame |
|---|---|---|
| 25 hydroxyvitamin D | To describe the vitamin D status,ng/mL. | through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Demographic data | age, gender, ethnicity | through study completion, an average of 1 year |
| Environmental data | season,region type, latitude, ambient ultraviolet B radiation level |
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Inclusion Criteria:
Participanted in China national nutrition and health survey (CNNHS) 2010-2012; Aged 6-17 years; Had blood taken;
Exclusion Criteria: No.
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The participants of this study were aged 6-17y selected from the Chinese national nutrition and health survey
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| Name | Affiliation | Role |
|---|---|---|
| Lichen Yang | National Institute for Nutrition and Health, China CDC | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Institute for Nutrition and Health, China CDC | Beijing | Beijing Municipality | 100050 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17634462 | Background | Holick MF. Vitamin D deficiency. N Engl J Med. 2007 Jul 19;357(3):266-81. doi: 10.1056/NEJMra070553. No abstract available. | |
| 21796828 | Background | Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Dietary Reference Intakes for Calcium and Vitamin D. Washington (DC): National Academies Press (US); 2011. Available from http://www.ncbi.nlm.nih.gov/books/NBK56070/ |
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| ID | Type | URL | Comment |
|---|---|---|---|
| Study Protocol | View IPD |
The total database of CNHHS 2010-2012 including the database used in our study cannot be made public before the publication of nutrition survey monographs.
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| ID | Term |
|---|---|
| D014808 | Vitamin D Deficiency |
| ID | Term |
|---|---|
| D001361 | Avitaminosis |
| D003677 | Deficiency Diseases |
| D044342 | Malnutrition |
| D009748 | Nutrition Disorders |
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2 mL of fasting venous blood was collected and centrifuged at 1500×g for 15 minutes within 30 minutes after blood taken. The upper serum was aliquoted and stored in brown vessel at -20℃ in the laboratory where the investigation point was located. All the serum specimens from all the 150 investigation points were transported to our laboratory by cold chain. All the samples were preserved at -70℃ refrigerator before determination.
| up to 25 weeks |
| Outdoor time | outdoor activity time | through study completion, an average of 1 year |
| Vitamin D supplementation | frequency of vitamin D supplements taking for each participant | through study completion, an average of 1 year |
| 25266429 | Background | Golden NH, Abrams SA; Committee on Nutrition. Optimizing bone health in children and adolescents. Pediatrics. 2014 Oct;134(4):e1229-43. doi: 10.1542/peds.2014-2173. |
| 21646368 | Result | Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, Murad MH, Weaver CM; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385. Epub 2011 Jun 6. |
| 23266927 | Result | Turer CB, Lin H, Flores G. Prevalence of vitamin D deficiency among overweight and obese US children. Pediatrics. 2013 Jan;131(1):e152-61. doi: 10.1542/peds.2012-1711. Epub 2012 Dec 24. |
| 19951983 | Result | Mansbach JM, Ginde AA, Camargo CA Jr. Serum 25-hydroxyvitamin D levels among US children aged 1 to 11 years: do children need more vitamin D? Pediatrics. 2009 Nov;124(5):1404-10. doi: 10.1542/peds.2008-2041. |
| D009750 |
| Nutritional and Metabolic Diseases |