Protocol Establishment for the Prevention of Lamotrigine-induced Skin Rash in Epilepsy Patients

Protocol Establishment for the Prevention of Lamotrigine-induced Skin Rash in Epilepsy Patients: A Pilot Study

The investigators intend to find a way to lower drug rash occurrence by applying drug tolerance induction protocol at the beginning of lamotrigine administration.

Genotyping of participants with rash and those without rash after taking lamotrigine and genetic testing to find common gene mutations in these participants.

Inclusion Criteria:

• Adults aged 18-85 years old
• Epilepsy patients
• Patients who started Lamotrigine first time

Exclusion Criteria:

• Those who do not agree with prior consent
• Women taking oral contraceptives.
• history of drug rash
• Taking enzyme-inducing antiepileptic drugs (EIAED) or valproate (VPA)