Surgical Pleth Index (SPI) Versus Standard Clinical Approach Analgesia

Surgical Pleth Index Guided Intraoperative Analgesia Versus Standard Clinical Approach During Desflurane Based General Anesthesia for Thyroidectomy

The study is aimed at confronting a surgical pleth index based protocol for intraoperative analgesia in a desflurane based general anesthesia for thyroidectomy, versus a standard clinical approach. A reduction in analgesic consumption and improvement in hemodynamics are expected.

Inclusion Criteria:

• 18<age<80 years
• American society of anesthesiology (ASA) physical status I -II
• 6 hrs fasting

Exclusion Criteria:

• Arrhythmia or Pacemaker
• Central or peripheral nervous system or muscular disease
• Drugs active on autonomous nervous system (eg clonidine)
• Obesity (BMI >35)
• Chronic Pain
• Addictions or central nervous acting drugs use
• Hypertension (if not treated)
• Connective tissue disease
• Pregnancy
• Allergy or hypersensitivity to study drugs
• QT prolongation
• Absence of inclusion criteria