Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The study is aimed at determining the remifentanil effect site concentration suppressing the cough at extubation after surgical thyroidectomy, performed under remifentanil/desflurane based general anesthesia, expressed as median and 95th percentile effective dose.
Possible hemodynamic instability, respiratory depression or prolongation of awakening time are also sought.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| remifentanil | Experimental | After skin suture, a predetermined Effect site remifentanil concentration will be achieved. Starting from 1.5 ng/ml in the first patient and increased or decreased by 0.2 ng/ml intervals based on the previous patient response: up if cough present, down otherwise ("Dixon's up and down" method). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Remifentanil Effect site concentration | Other | After skin suture, a predetermined Effect site remifentanil concentration will be achieved. Starting from 1.5 ng/ml in the first patient and increased or decreased by 0.2 ng/ml intervals based on the previous patient response: up if cough present, down otherwise ("Dixon's up and down" method). |
| Measure | Description | Time Frame |
|---|---|---|
| Cough | Any episode of sudden and violent abdominal contraction interrupting normal quite spontaneous or assisted ventilation would be accounted as "cough" and defines non-smooth extubation | 15 minutes after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Hemodynamics 1 | Heart Rate (bpm) | 15 minutes after surgery |
| Hemodynamics 2 | Blood pressure (mmHg) | 15 minutes after surgery |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Paolo Onida, MD | Contact | +39 07051096543 | paolo.onida80@gmail.com | |
| Paolo Mura, MD | Contact | +39 07051096543 | mura_paolo@hotmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Gabriele Finco, MD | Cagliari University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Policlinico Duilio Casula | Monserrato | Cagliari | 09072 | Italy |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D003371 | Cough |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
Not provided
Not provided
Prospective observational study. Decreasing/increasing remifentanil effect site concentrations (Dixon's up and down model) to obtain cough-free extubation after thyroidectomy
Not provided
Not provided
Patient under general anesthesia unaware of the effect site concentration of remifentanil before extubation
Not provided
|
| Respiratory outcome 1 | Tidal Volume (ml) | 15 minutes after surgery |
| Respiratory outcome 2 | End Tidal Carbon Dioxide (mmHg) | 15 minutes after surgery |
| D013568 | Pathological Conditions, Signs and Symptoms |