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| Name | Class |
|---|---|
| CardioVascular Research Foundation, Korea | OTHER |
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The primary objective of the POST-PCI trial is to compare the clinical outcomes of a post-percutaneous coronary intervention(PCI) aggressive management strategy of routine noninvasive functional testing to a usual-care strategy of symptom-oriented functional testing in patients with high risk clinical, anatomical, and procedural characteristics who received PCI with contemporary drug-eluting stent and bioresorbable vascular scaffold.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No Routine stress testing after PCI | Active Comparator |
| |
| Routine stress testing at 9~15 months after PCI | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| routine stress testing | Diagnostic Test | In the group of routine stress testing group, the preselected functional test (exercise ECG, nuclear stress testing, or stress echocardiography) will be performed at 9~15 months after the procedure according to the practice pattern of each participating center. |
| Measure | Description | Time Frame |
|---|---|---|
| composite of major cardiovascular events | a composite of major cardiovascular events that included death from any cause, myocardial infarction, or hospitalization for unstable angina. | 2 year |
| Measure | Description | Time Frame |
|---|---|---|
| Death | 2 year | |
| Myocardial infarction | 2 year | |
| Unstable angina hospitalization |
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Inclusion Criteria:
Subject was > 19 years of age.
Subjects who underwent successful percutaneous coronary intervention with contemporary drug eluting stent, contemporary Bioresorbable Scaffold or drug eluting balloon at In-stent restenosis (ISR) lesion.
Patients must have at least one of the following high-risk clinical, lesion, or procedure-related risk factors.
3-1. Clinical factors; diabetes, renal insufficiency/failure, enzyme positive acute coronary syndrome (ACS) (STEMI or NSTEMI).
3-2. Lesion- or procedure-related factors ; left main lesion, bifurcation lesion, ostial lesion, chronic total occlusion lesion, multivessel disease (≥ 2 vessels stented), restenotic lesion, diffuse long lesion (lesion length ≥30 mm or stent length ≥32 mm), or vein bypass graft stented
The patient or guardian agrees to the study protocol and the schedule of clinical follow-up, and provides informed, written consent, as approved by the appropriate Institutional Review Board/Ethical Committee of the respective clinical site.
Exclusion Criteria:
6 Subject was unable to provide written informed consent or participate in long-term follow-up.
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| Name | Affiliation | Role |
|---|---|---|
| Duk-woo Park, MD | Asan Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gangwon National Univ. Hospital | Chuncheon | South Korea | ||||
| Daegu Catholic University Medical Center |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41043864 | Derived | Choi Y, Kang DY, Kim H, Lee J, Jo S, Ahn JM, Kim N, Yoon YH, Hur SH, Lee CH, Kim WJ, Kang SH, Park CS, Lee BK, Suh JW, Choi JW, Kim KS, Lee SN, Park SJ, Park DW; POST-PCI Investigators. Role of routine surveillance stress testing in patients with or without imaging-guided or physiology-guided PCI. Heart. 2025 Oct 2:heartjnl-2025-326402. doi: 10.1136/heartjnl-2025-326402. Online ahead of print. | |
| 38922632 |
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|
| No Routine stress testing | Diagnostic Test | In the group of symptom oriented stress testing group, the preselected functional test (exercise ECG, nuclear stress testing, or stress echocardiography) will be performed when chest pain or angina symptom is occured after the procedure according to the practice pattern of each participating center. |
|
| 2 year |
| Death or myocardial infarction | 2 year |
| Any hospitalization | cardiac cause vs. noncardiac cause | 2 year |
| Invasive catheterization | 2 year |
| Repeat revascularization procedure | Repeat revascularization procedure during follow-up; target vs. non-target lesion (or vessel), ischemia-driven vs. not ischemia-driven. | 2 year |
| Daegu |
| South Korea |
| Keimyung University Dongsan Medical Center | Daegu | South Korea |
| Chungnam National University Hospital | Daejeon | South Korea |
| Bundang CHA Hospital | Seongnam | South Korea |
| Seoul National University Bundang hospital | Seongnam | South Korea |
| Asan Medical Center | Seoul | South Korea |
| Eulji General Hospital | Seoul | South Korea |
| The Catholic University of Korea, Yeouido St. Mary's Hospital | Seoul | South Korea |
| The Catholic university of Korea, ST. Vincent's Hospital | Suwon | South Korea |
| Wonju Severance Christian Hospital | Wŏnju | South Korea |
| Derived |
| Lee J, Kang DY, Kim H, Choi Y, Jo S, Ahn JM, Kim S, Yoon YH, Hur SH, Lee CH, Kim WJ, Kang SH, Park CS, Lee BK, Suh JW, Choi JW, Kim KS, Lee SN, Park SJ, Park DW. Routine Stress Testing After PCI in Patients With and Without Acute Coronary Syndrome: A Secondary Analysis of the POST-PCI Randomized Clinical Trial. JAMA Cardiol. 2024 Sep 1;9(9):770-780. doi: 10.1001/jamacardio.2024.1556. |
| 38418002 | Derived | Lee JM, Kim H, Park YS, Jo HH, Lim SM, Lee J, Choi Y, Kang DY, Ahn JM, Kim S, Yoon YH, Hur SH, Lee CH, Kim WJ, Kang SH, Park CS, Lee BK, Suh JW, Choi JW, Kim KS, Lee SN, Park SJ, Park DW; POST-PCI Investigators. Surveillance Stress Testing After Percutaneous Intervention for Patients With Multivessel or Left Main Coronary Disease. J Am Coll Cardiol. 2024 Mar 5;83(9):890-900. doi: 10.1016/j.jacc.2023.12.027. |
| 36036496 | Derived | Park DW, Kang DY, Ahn JM, Yun SC, Yoon YH, Hur SH, Lee CH, Kim WJ, Kang SH, Park CS, Lee BK, Suh JW, Yoon JH, Choi JW, Kim KS, Choi SW, Lee SN, Park SJ; POST-PCI Investigators. Routine Functional Testing or Standard Care in High-Risk Patients after PCI. N Engl J Med. 2022 Sep 8;387(10):905-915. doi: 10.1056/NEJMoa2208335. Epub 2022 Aug 28. |
| ID | Term |
|---|---|
| C564258 | Coronary Artery Disease, Autosomal Dominant, 1 |
| D000789 | Angina, Unstable |
| ID | Term |
|---|---|
| D000787 | Angina Pectoris |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D002637 | Chest Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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