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Nutrition is a major issue for premature infants. Inappropriate nutritional intake during the first weeks of life is responsible for postnatal growth restriction and adverse long-term outcomes.
This study aimed at evaluating the impact of the introduction of an updated, standardized, nutrition protocol on very premature infants' growth and morbidity, and the care givers' compliance to the new protocol.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Before Protocol | 72 premature infants born between 26 and 32 weeks gestation, over 6 months period, and involved before the introduction of a strict nutrition protocol |
| |
| After Protocol | 86 premature infants born between 26 and 32 weeks gestation, over 6 months period, and involved after the introduction of a strict nutrition protocol and a washout period of 6 months |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| nutrition protocol introduction | Other | Growth comparison of 2 cohorts of infants evaluated in a before-after design |
|
| Measure | Description | Time Frame |
|---|---|---|
| weight | longitudinal weight evaluation | weekly recording from Day 0 up to Day 77 |
| Measure | Description | Time Frame |
|---|---|---|
| Necrotizing enterocolitis | Necrotizing enterocolitis | Day 77 postnatal age |
| late onset sepsis | Incidence of late onset sepsis | Day 77 postnatal age |
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Inclusion Criteria:
Exclusion Criteria:
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All infants born between 26 to 32 weeks gestation and admitted to our level III NICU were eligible and included in the study
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32437423 | Derived | Wittwer A, Hascoet JM. Impact of introducing a standardized nutrition protocol on very premature infants' growth and morbidity. PLoS One. 2020 May 21;15(5):e0232659. doi: 10.1371/journal.pone.0232659. eCollection 2020. |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| patent ductus arteriosus | Incidence of patent ductus aretriosus requiring treatment | Day 77 postnatal age |
| Bronchopulmonary dysplasia | Incidence of Bronchopulmonary dysplasia | Day 77 postnatal age |
| Central venous catheters. | Duration of central venous catheters | Day 77 postnatal age |
| Compliance to the protocol | comparison between expected prescription and actual nutrition intake | weekly recording from Day 0 up to Day 77 |
| D000091642 | Urogenital Diseases |