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| ID | Type | Description | Link |
|---|---|---|---|
| 2017-A00737-46 | Other Identifier | ANSM |
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There is no prospective study published on the Essential Thrombocythemia and the correlation between this specific disease, its complications and the biological variations observed.
The aim of this study is to demonstrate a correlation between biological tests of haemostasis, as Multiplate analyser and thromboelastometry (ROTEM) and the occurrence of clinical complications, thrombosis and/or haemorrhage, in order to determine if this biological tests could be biological prognostic factors
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with Essential Thrombocythemia | Other | patients who come in consultation at diagnosis or during the follow-up for an Essential Thrombocythemia. They will have biological tests of haemostasis at each consultation (Multiplate, ROTEM, VASP) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| biological tests of haemostasis at each consultation (Multiplate, ROTEM, VASP) | Biological | Patients will have blood samples at each consultation (2 or 3 sampling tubes) in order to carry out systematically three biological tests |
| Measure | Description | Time Frame |
|---|---|---|
| Occurrence of thrombotic complications | All thrombotic complications will be gathered by the investigators during the four months following the realization of Multiplate and ROTEM test | every 4 months, up to 18 months |
| Occurrence of haemorrhagic complications | All haemorrhagic complications will be gathered by the investigators during the four months following the realization of Multiplate and ROTEM test | every 4 months, up to 18 months |
| Measure | Description | Time Frame |
|---|---|---|
| Occurrence of thrombotic complications | All thrombotic complications will be gathered by the investigators during the four months following the realization of VASP test | every 4 months, up to 18 months |
| Occurrence of haemorrhagic complications |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Fiorenza BARRACO, MD | Hospices Civils de Lyon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Lyon Sud | Pierre-Bénite | 69495 | France |
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All haemorrhagic complications will be gathered by the investigators during the four months following the realization of VASP test
| every 4 months, up to 18 months |
| Changes of tests results according to medical treatments | All modifications of medical treatments will be gathered at each consultation to analyse changes of biological tests results | every 4 months, up to 18 months |
| Description of platelet physiopathology | Using a specific test of release of ATP to study the platelet physiopathology in Essential Thrombocythemia only for patients seen at diagnosis and naive of all medical treatment | the day of inclusion |
| Description of platelet physiopathology | Using electronic microscopy to study the platelet physiopathology in Essential Thrombocythemia only for patients seen at diagnosis and naive of all medical treatment | the day of inclusion |
| ID | Term |
|---|---|
| D013920 | Thrombocythemia, Essential |
| D006470 | Hemorrhage |
| D013927 | Thrombosis |
| ID | Term |
|---|---|
| D001778 | Blood Coagulation Disorders |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D013922 | Thrombocytosis |
| D001791 | Blood Platelet Disorders |
| D009196 | Myeloproliferative Disorders |
| D001855 | Bone Marrow Diseases |
| D006474 | Hemorrhagic Disorders |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D016769 | Embolism and Thrombosis |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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