Pharmacokinetics and Metabolism of [14C] BMS-986231 in Healthy Male Participants

Pharmacokinetics and Metabolism of [14C] BMS-986231 in Healthy Male Participants

An intravenous infusion in healthy subjects to obtain information about the absorption, metabolism, and excretion (AME) of BMS-986231

Inclusion Criteria:

• Signed Informed Consent
• Target population: Healthy males with no clinically significant deviations from normal in medical history, physical examinations, vital signs, electrocardiograms (ECGs), physical measurements, and clinical laboratory tests
• Body weight between 75 and 95 kg, inclusive; body mass index (BMI) between 18 to 32 kg/m2.

Exclusion Criteria:

• History of chronic illness
• Chronic headaches
• Recurrent dizziness
• Personal or family history of heart disease
• Personal history of bleeding diathesis

Other protocol defined inclusion/exclusion criteria could apply