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| Name | Class |
|---|---|
| American Heart Association | OTHER |
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This retrospective multicenter cohort will validate an independent association of electrocardiographic (ECG) global electrical heterogeneity (GEH) measures with sustained ventricular tachyarrhythmias and appropriate ICD therapies in systolic heart failure patients with primary prevention ICD, and will validate and re-calibrate GEH ECG risk score for prediction of sustained ventricular tachyarrhythmias and appropriate ICD therapies in systolic heart failure patients with primary prevention ICD.
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| Measure | Description | Time Frame |
|---|---|---|
| Primary outcome: sustained VT/VF event with appropriate ICD therapy (either ATP or shock) | Sustained ventricular tachyarrhythmia event with appropriate ICD therapy (either antitachycardia pacing or shock) | up to 15 years |
| Primary competing outcome: All-cause death without preceding sustained VT/VF with appropriate ICD therapy | All-cause death without preceding sustained ventricular tachyarrhythmia with appropriate ICD therapy | up to 15 years |
| Measure | Description | Time Frame |
|---|---|---|
| sustained monomorphic ventricular tachycardia | Sustained monomorphic ventricular tachycardia with appropriate ICD therapies (either antitachycardia pacing or ICD shock) | up to 15 years |
| sustained polymorphic ventricular tachycardia / ventricular fibrillation |
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Inclusion Criteria:
Exclusion Criteria:
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retrospective records of systolic heart failure patients with primary prevention ICDs/CRT-Ds implanted for routine clinical indications
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| Name | Affiliation | Role |
|---|---|---|
| Larisa G Tereshchenko, MD, PhD | Oregon Health and Science University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | United States | ||
| Stanford University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29541969 | Background | Waks JW, Hamilton C, Das S, Ehdaie A, Minnier J, Narayan S, Niebauer M, Raitt M, Tompkins C, Varma N, Chugh S, Tereshchenko LG. Improving sudden cardiac death risk stratification by evaluating electrocardiographic measures of global electrical heterogeneity and clinical outcomes among patients with implantable cardioverter-defibrillators: rationale and design for a retrospective, multicenter, cohort study. J Interv Card Electrophysiol. 2018 Jun;52(1):77-89. doi: 10.1007/s10840-018-0342-2. Epub 2018 Mar 14. | |
| 33684549 |
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| ID | Term |
|---|---|
| D006333 | Heart Failure |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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sustained polymorphic ventricular tachycardia or ventricular fibrillation with appropriate ICD therapies (either antitachycardia pacing or ICD shock) |
| up to 15 years |
| Stanford |
| California |
| 94305 |
| United States |
| University of Colorado | Aurora | Colorado | 80045 | United States |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | United States |
| Oregon Health and Science University | Portland | Oregon | 97239 | United States |
| Veteran Administration Portland Healthcare System | Portland | Oregon | 97239 | United States |
| Result |
| Waks JW, Haq KT, Tompkins C, Rogers AJ, Ehdaie A, Bender A, Minnier J, Dalouk K, Howell S, Peiris A, Raitt M, Narayan SM, Chugh SS, Tereshchenko LG. Competing risks in patients with primary prevention implantable cardioverter-defibrillators: Global Electrical Heterogeneity and Clinical Outcomes study. Heart Rhythm. 2021 Jun;18(6):977-986. doi: 10.1016/j.hrthm.2021.03.006. Epub 2021 Mar 6. |
| 33872969 | Result | Haq KT, Javadekar N, Tereshchenko LG. Detection and removal of pacing artifacts prior to automated analysis of 12-lead ECG. Comput Biol Med. 2021 Jun;133:104396. doi: 10.1016/j.compbiomed.2021.104396. Epub 2021 Apr 19. |
| 38703375 | Derived | Tereshchenko LG, Waks JW, Tompkins C, Rogers AJ, Ehdaie A, Henrikson CA, Dalouk K, Raitt M, Kewalramani S, Kattan MW, Santangeli P, Wilkoff BW, Kapadia SR, Narayan SM, Chugh SS. Competing risks of monomorphic vs. non-monomorphic ventricular arrhythmias in primary prevention implantable cardioverter-defibrillator recipients: Global Electrical Heterogeneity and Clinical Outcomes (GEHCO) study. Europace. 2024 Jun 3;26(6):euae127. doi: 10.1093/europace/euae127. |