Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Clinical Investigation Centre for Innovative Technology Network | NETWORK |
Not provided
Not provided
Not provided
Not provided
Evaluation and comparison of histological analysis, 9,4 tesla MRI, Full-Field Optical Coherence Tomography (FFOCT) and ultrasound-based navigation system for cartilage degeneration analysis of patellofemoral joint.
Knee osteoarthritis (OA) is a common and debilitating chronic degenerative disease of the articular cartilage. Despite recent progress in the field of cartilage imaging, no routinely used clinical imaging modality has the ability to evaluate and monitor changes in cartilage degeneration. This observationnal, pilot, prospective, non randomized, uncontrolled, monocentric study aim to compare three of the most innovative imaging systems, namely the 9,4 Tesla MRI, the FFOCT (Full-Field Optical Coherence Tomography) and the ultrasound-based navigation system in order to image healthly to severely degraded human cartilage samples. All methods will be cross-correlated and compared with histological data considered as the gold standard.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Imaging measurements | All subject of the study have a knee osteoarthritis (OA) and are going to have a knee prosthetic surgery with cartilage excision. Multimodal evaluation is conducted on ex vivo human cartilage samples (2 samples per patient are selected : healthy and severely degraded). |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation and comparison of histologic analysis, 9,4 Tesla MRI, FFOCT and ultrasound-based navigation system for cartilage lesions analysis of patellofemoral joint. | Correlation between Osteoarthritis Research Society International (OARSI) grades performed for different modalities | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of 9,4 Tesla MRI reconstructions in early osteoarthritis evaluation using visual qualitative information parameter obtained from the Average Pathlength Maps (APM). | Correlation between MRI quantitative parameters and gold standard OARSI grade | 6 months |
| Evaluation of FFOCT reconstructions in early osteoarthritis evaluation using visual qualitative information parameter. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Patients with knee arthroplasty indication for medial femoro-tibial osteoarthristis at University Hospital, Grenoble
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Alexandre Moreau-Gaudry, MD, PhD | Clinical Investigation Centre for Innovative Technology Network | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Orthopedic Surgery Department, University Grenoble Hospital | Grenoble | 38043 | France |
Not provided
| Label | URL |
|---|---|
| Clinical Investigation Centre for Innovative Technology Network website | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D020370 | Osteoarthritis, Knee |
| ID | Term |
|---|---|
| D010003 | Osteoarthritis |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
Not provided
Not provided
Not provided
Not provided
Not provided
cartilage samples undergoing total knee arthroplasty procedure
Correlation between quantitative parameters from FFOCT and gold standard OARSI grade |
| 6 months |
| Evaluation of navigation ultrasound in early osteoarthritis evaluation using visual qualitative information parameter. | Correlation between quantitative parameters from navigation ultrasound and gold standard OARSI grade | 6 months |
| Evaluation of of 9,4 Tesla MRI reconstruction in early osteoarthritis evaluation using visual quantitative information parameter obtained for the Average Pathlength Maps. | Correlation between quantitative parameters from the Average Pathlength Maps and gold standard OARSI grade | 6 months |
| Evaluation of FFOCT reconstructions in early osteoarthritis evaluation using visual quantitative information parameter. | Thickness average of cartilage | 6 months |
| Evaluation of FFOCT reconstructions in early osteoarthritis evaluation using visual quantitative information parameter. | Roughness average of cartilage | 6 months |
| Evaluation of navigation ultrasound in early osteoarthritis evaluation using visual quantitative information parameter. | Thickness average of cartilage | 6 months |
| Inter-observer robustness analysis of the OARSI classification | Inter-observers Kappa coefficient | 6 months |
| Intra-observer robustness analysis of the OARSI classification | Intra-observers Kappa coefficient | 6 months |
| D012216 |
| Rheumatic Diseases |