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| Name | Class |
|---|---|
| Onze Lieve Vrouw Hospital | OTHER |
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The study compares in a randomized controlled way two stimulation methods. One of these stimulation methods implements a new insight in ovarian follicular growth. If this novel method of stimulation proves to be as efficient as the classical stimulation protocols, there might be a dramatic reduction of the costs of the medical therapy in IVF, thus reducing also the overall IVf costs significantly.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| low dose hCG (Pregnyl) | Experimental | Corifollitropin Alfa (Elonva) dosage depending on weight once administered first day of ovarian stimulation in combination 150IU low dose hCG from day 7 until final oocyte maturation. |
|
| hp-FSH (Menopur) | Active Comparator | Corifollitropin Alfa (Elonva) dosage depending on weight once administered first day of ovarian stimulation in combination with hp-FSH until final oocyte maturation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| low dose hCG | Drug |
|
| |
| hp-FSH |
| Measure | Description | Time Frame |
|---|---|---|
| The financial costs of the stimulation in both groups | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| The number of MII oocytes obtained at the occasion of the oocyte retrieval | 3 weeks | |
| pregnancy rate | 5 weeks | |
| duration of the stimulation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Wim Decleer, MD | FERTILITY CENTER AZ JAN PALFIJN | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AZ Jan Palfijn | Ghent | Oost-Vlaanderen | 9000 | Belgium |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| D006063 | Chorionic Gonadotropin |
| D008596 | Menotropins |
| C437186 | follicle stimulating hormone, human, with HCG C-terminal peptide |
| ID | Term |
|---|---|
| D006062 | Gonadotropins |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
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| Drug |
|
|
| Corifollitropin Alfa | Drug | Corifollitropin Alfa (Elonva) dosage depending on weight, once administered first day of ovarian stimulation for all subjects, and on day 7 they proceed with the treatment of the allocated group. <60 kg: Elonva 100 MCG > 60 kg: Elonva 150 MCG |
|
|
| one month |
| hormonal levels reached at time of induction of final maturation of the oocyte | 3 weeks |
| the number of clinical OHSS patients | one month |
| D010926 | Placental Hormones |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |
| D011257 | Pregnancy Proteins |
| D011506 | Proteins |
| D006065 | Gonadotropins, Pituitary |
| D010908 | Pituitary Hormones, Anterior |
| D010907 | Pituitary Hormones |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |