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Comparing the non-motor symptoms of patients with hereditary spastic paraplegia (HSP) to healthy controls (spouses, relatives or other healthy controls) by using the a number of specific questionaires
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HSP patients | Patients with hereditary spastic paraplegia regardless of their genetic mutation |
| |
| Healthy controls | healthy controls (spouses, relatives, or other healthy controls) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| EuroQol five dimensions questionaire (EQ-5D) | Diagnostic Test | Testing quality of life. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Identification of relevant non-motor symptoms in SPG4 | By using the five mentioned scales we try to identify relevant non-motor symptoms | day 1 |
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Inclusion Criteria:
Exclusion Criteria:
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We recruit known patients to our department or via patient interest groups.
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| Name | Affiliation | Role |
|---|---|---|
| Tim W. Rattay, MD | Researcher | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Tübingen, Center for Neurology | Tübingen | 72076 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31646384 | Result | Rattay TW, Boldt A, Volker M, Wiethoff S, Hengel H, Schule R, Schols L. Non-motor symptoms are relevant and possibly treatable in hereditary spastic paraplegia type 4 (SPG4). J Neurol. 2020 Feb;267(2):369-379. doi: 10.1007/s00415-019-09573-w. Epub 2019 Oct 23. |
| Label | URL |
|---|---|
| Link Citation (DOI) | View source |
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| Modified Fatigue Impact Scale (MFI) | Diagnostic Test | Screening for fatigue |
|
| Brief Pain Inventory (BPI) | Diagnostic Test | Testing for pain |
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| Becks Depression Inventory (BDI) | Diagnostic Test | Screening for depression |
|
| Restless-leg Questionaire (RLS diagnostic criteria) | Diagnostic Test | Testing for restless-legs |
|