Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients

Arachidonic Acid Metabolism in Carotid Stenosis Plaque in Diabetic Patients

Diabetes is associated with an increased risk of cardiovascular complications, as a reflection of the chronic inflammatory status. Monocytes-macrophages in diabetic subjects present impaired arachidonic acid metabolism. Moreover, atheromatous plaques in diabetic subjects seem to be significantly enriched in 2-AA-LPC (2-arachidonoyl-lysophosphatidylcholine) and are more inflammatory and more likely to rupture than are plaques in non-diabetic subjects. We therefore hypothesize that this vulnerability of atheromatous plaques in diabetic subjects could be explained by impaired 2-AA-LPC metabolism within the plaque.

Inclusion Criteria:

• Patients who have provided explicit consent
• Patients older than 18 years
• Patients about to undergo surgery for carotid stenosis
• Haemoglobin ≥ 7g/dl at the time the sample is taken
• Respect the maximum volume of blood taken (treatment + research) in 30 days

SPECIFIC TO DIABETICS

- Patients with type 1 or 2 diabetes diagnosed more than 6 months earlier

Exclusion Criteria:

• Patients under guardianship
• Patients without health insurance cover
• Pregnant or breast-feeding women