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| Name | Class |
|---|---|
| North Dakota Beef Commission | UNKNOWN |
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The purpose of this study is to determine the effects of daily protein intake patterns on body composition and eating behaviors during weight loss.
The reinforcing value of food varies greatly among individuals, but is strongest for those who are overweight or obese. Reducing energy intake, which is necessary for overweight and obese individuals to achieve a healthier body weight, increases the reinforcing value of food - especially for energy-dense snack foods. Food is a powerful reinforcer and is associated with energy intake; making it a primary contributing factor to an individual's weight loss struggle. Developing a way to decrease or limit the increase in food reinforcement during energy deficits would have important clinical impact. High-protein diets are known to be efficacious for weight loss and recently have been shown to decrease stimulation of the reward areas of the brain that stimulate reward-driven eating behavior. Nonetheless, sustaining a high-protein diet can be difficult, especially for women. Consuming a modest amount of protein at each meal may be better tolerated. However, we do not know whether this pattern of protein intake can assist women in staying "on track" with weight loss goals. This study will help begin to elucidate the connections between the daily pattern of protein intake on diet adherence, alterations in food reinforcement, and favorable body composition changes during weight loss.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Even protein intake | Experimental | Menu to provide 90 g of protein per day in an even distribution of 30 g at each meal. |
|
| Skewed protein intake | Experimental | Menu to provide 90 g of protein per day in a skewed distribution of 10 g at breakfast, 15 g at lunch and 65 g at dinner. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Even protein | Other | Intake of even protein 5 day rotating menu |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Body Composition | Determine the effects of two patterns of daily protein intake on changes in fat mass and fat-free mass during weight loss. | 8 and 16 weeks |
| Diet Adherence | Determine the effects of two patterns of daily protein intake on weight loss diet adherence and putative mediators (satisfaction, satiety, hunger, and reinforcing value of energy dense foods) of adherence. | 16 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Barriers to weight control | Nominal Group Technique results providing an exhaustive list of barriers to weight control in overweight and obese women | 1 hour |
| Change in skeletal muscle protein breakdown |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Shanon Casperson, PhD | USDA Grand Forks Human Nutrition Research Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| USDA Grand Forks Human Nutrition Research Center | Grand Forks | North Dakota | 58203 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38365118 | Derived | De Leon A, Roemmich JN, Casperson SL. Daily Dietary Protein Distribution Does Not Influence Changes in Body Composition During Weight Loss in Women of Reproductive Years with Overweight or Obesity: A Randomized Controlled Trial. J Nutr. 2024 Apr;154(4):1347-1355. doi: 10.1016/j.tjnut.2024.02.009. Epub 2024 Feb 15. |
| Label | URL |
|---|---|
| Grand Forks Human Nutrition Research Center Current Nutrition Studies | View source |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| ICF | No | No | Yes | Informed Consent Form | Jan 27, 2023 | Oct 30, 2023 | ICF_000.pdf |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D015431 | Weight Loss |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| Skewed protein |
| Other |
Intake of skewed protein 5 day rotating menu |
|
The effect of consuming two patterns of daily protein intake on 3-Methylhistidine degradation, a biochemcial marker of skeletal muscle protein breakdown
| 8 and 16 weeks |
| Circulating carotenoid levels | The effect of consuming two patterns of protein intake during weight loss on circulating carotenoid levels. | 8 and 16 weeks |
| Relative reinforcing value (RRV) of food | The effect of consuming two patterns of daily protein intake during weight loss on the RRV of energy-dense snack food | 8 and 16 weeks |
| Change in bone turnover | The effect of consuming two patterns of daily protein intake during weight loss on osteocalcin, alkaline phosphatase, acid phosphatase, and collagen cross-link molecules -- biochemical markers of bone formation and resorption | 8 and 16 weeks |
| Plasma lipids | The effect of consuming two patterns of daily protein intake during weight loss on lipid and triglyceride molecular speciation. | 8 and 16 weeks |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001836 | Body Weight Changes |