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| Name | Class |
|---|---|
| The University of Hong Kong | OTHER |
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Information regarding the optimal timing for frozen-thawed embryo transfer (FET) following a stimulated in vitro fertilization (IVF) is lacking. One option is to perform FET in the first cycle following the stimulated IVF cycle, i.e. immediate transfer. Another option is to postpone FET for at least one menstrual cycle, i.e. delayed transfer. This randomized study aims to compare the ongoing pregnancy rate of immediate versus delayed FET following a stimulated IVF cycle.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| immediate group | Other | the intervention: immediate frozen-thawed embryo transfer (FET) which means FET will be performed in the first cycle following the stimulated IVF cycle |
|
| delayed group | Other | the intervention: delayed frozen-thawed embryo transfer (FET) which means FET will be performed at least in the second cycle following the stimulated IVF cycle |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| immediate frozen-thawed embryo transfer | Other | Frozen-thawed embryo transfer will be performed in the first cycle following the stimulated IVF cycle |
|
| Measure | Description | Time Frame |
|---|---|---|
| ongoing pregnancy | viable pregnancy beyond gestation 12 weeks | viable pregnancy beyond gestation 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Positive hCG level | the result of serum β-hCG ≥10 mIU/mL. | A blood pregnancy test is performed 14 days after the FET |
| clinical pregnancy | presence of intrauterine gestational sac on ultrasound |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| XIAOXI SUN, PHD | Shanghai JiAi Genetics & IVF Institute | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ShangHai JIAI Genetics&IVF Institute | Shanghai | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26806686 | Background | Santos-Ribeiro S, Siffain J, Polyzos NP, van de Vijver A, van Landuyt L, Stoop D, Tournaye H, Blockeel C. To delay or not to delay a frozen embryo transfer after a failed fresh embryo transfer attempt? Fertil Steril. 2016 May;105(5):1202-1207.e1. doi: 10.1016/j.fertnstert.2015.12.140. Epub 2016 Jan 21. | |
| 27609984 | Background |
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Individual participant data that underlie the results after deidentification (text, tables, figures, and appendices) and study protocol will be shared. Data will be available when beginning 3 months and ending 5 years following article publication. To achieve aims in the approved proposal, researchers who provide a methodologically sound proposal will be shared with.Data will be made available by the following way. Proposals should be directed to lihe198900@163.com. And data are available for 5 years at a third party website (link to be included after the article publication).
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No masking because of the nature of the intervention
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| delayed frozen-thawed embryo transfer | Other | Frozen-thawed embryo transfer will be performed at least in the second cycle following the stimulated IVF cycle |
|
| presence of intrauterine gestational sac on ultrasound at 6 weeks of pregnancy |
| biochemical pregnancy: | positive blood pregnancy test not followed by clinical pregnancy | positive blood pregnancy test not followed by clinical pregnancy during 12 weeks gestation |
| implantation rate | number of gestational sacs per embryo transferred | number of gestational sacs per embryo transferred during 4 weeks of pregnancy |
| multiple pregnancy | more than one intrauterine sacs on scanning | multiple pregnancy beyond gestation 12 weeks |
| ectopic pregnancy | pregnancy outside the uterine cavity | ectopic pregnancy during 12 weeks gestation |
| miscarriage | the loss of a pregnancy before 22 weeks gestation | the loss of a pregnancy before 22 weeks gestation |
| live birth rate | the rate of live births per cycle | a live birth after 22 weeks gestation |
| birth weight | birth weight of the baby delivered | a live birth after 22 weeks gestation |
| Santos-Ribeiro S, Polyzos NP, Lan VT, Siffain J, Mackens S, Van Landuyt L, Tournaye H, Blockeel C. The effect of an immediate frozen embryo transfer following a freeze-all protocol: a retrospective analysis from two centres. Hum Reprod. 2016 Nov;31(11):2541-2548. doi: 10.1093/humrep/dew194. Epub 2016 Sep 8. |
| 27986819 | Background | Lattes K, Checa MA, Vassena R, Brassesco M, Vernaeve V. There is no evidence that the time from egg retrieval to embryo transfer affects live birth rates in a freeze-all strategy. Hum Reprod. 2017 Feb;32(2):368-374. doi: 10.1093/humrep/dew306. Epub 2016 Dec 16. |
| 28041829 | Background | Volodarsky-Perel A, Eldar-Geva T, Holzer HE, Schonberger O, Reichman O, Gal M. Cryopreserved embryo transfer: adjacent or non-adjacent to failed fresh long GnRH-agonist protocol IVF cycle. Reprod Biomed Online. 2017 Mar;34(3):267-273. doi: 10.1016/j.rbmo.2016.11.013. Epub 2016 Dec 16. |
| 33885131 | Derived | Li H, Sun X, Yang J, Li L, Zhang W, Lu X, Chen J, Chen H, Yu M, Fu W, Peng X, Chen J, Ng EHY. Immediate versus delayed frozen embryo transfer in patients following a stimulated IVF cycle: a randomised controlled trial. Hum Reprod. 2021 Jun 18;36(7):1832-1840. doi: 10.1093/humrep/deab071. |
| 29773699 | Derived | Li H, Li L, Lu X, Sun X, Ng EHY. Comparison of the effect of immediate versus delayed transfer following a stimulated IVF cycle on the ongoing pregnancy rate of frozen-thawed embryo transfer cycles: a study protocol for a randomised controlled trial. BMJ Open. 2018 May 17;8(5):e020507. doi: 10.1136/bmjopen-2017-020507. |