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The study purpose is to investigate the hypothesis that in adults with SAH, early neuromuscular electrical stimulation (NMES) and high protein supplementation (HPRO) will improve muscle mass, metabolic and inflammatory biomarker profiles, compared to SAH controls receiving standard of care interventions for nutrition and mobilization. The investigators will accomplish this by studying the effects of a high protein (HPRO) nutritional treatment as well as NMES intervention have upon muscle wasting and motor strength acutely after SAH. This will be addressed in a prospective trial of SAH patients receiving HRPO with NMES as compared to age and severity-matched SAH patients undergoing standard of care interventions for nutrition and mobilization. Additionally, the study will investigate the impact HPRO and NMES interventions have upon inflammatory cytokines and markers of energy balance. Results of this study will establish evidence for precision nutrition plus early exercise to mitigate the catabolic and inflammatory state produced by SAH to improve muscle, metabolic, and health recovery outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Standard of Care | No Intervention | Patients will receive standard of care mobilization and nutritional supplementation throughout the study period. | |
| HPRO + NMES | Experimental | Patients will receive high protein supplementation(HPRO) administered within 30 minutes after each NMES session and additionally once at approximately 10 PM. |
|
| NMES only | Experimental | Patients will undergo two 30 minute NMES sessions per day during study period. |
|
| HPRO only | Experimental | Patients will receive HPRO three times daily during study period |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Neuromuscular Electrical Stimulation (NMES) | Device | Neuromuscular electrical stimulation twice daily during study period. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in muscle layer thickness of the quadriceps muscle as measured by muscle ultrasound scan at the end of study period. | Change in the muscle layer thickness of the quadriceps muscle as measured by ultrasound. | 14 days |
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Inclusion criteria:
Exclusion criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Neeraj Badjatia, MD MSc | Contact | 4103284515 | nbadjatia@umm.edu |
| Name | Affiliation | Role |
|---|---|---|
| Neeraj Badjatia, MD MSc | University of Maryland, Baltimore | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Maryland Medical Center | Recruiting | Baltimore | Maryland | 21201 | United States |
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| ID | Term |
|---|---|
| D013345 | Subarachnoid Hemorrhage |
| D009133 | Muscular Atrophy |
| D007249 | Inflammation |
| D008659 | Metabolic Diseases |
| ID | Term |
|---|---|
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| High Protein Supplementation | Dietary Supplement | High protein supplementation with whey protein shakes taken three times a day during study period. |
|
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D012816 | Signs and Symptoms |
| D009750 | Nutritional and Metabolic Diseases |