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The study proposes to compare the results of two examinations at 1.5 and 3 Tesla obtained on the same day on a series of 80 patients.
Quantification of hepatic iron by MRI is validated at 1.5 Tesla on a small number of subjects with some discrepancies between the two most used techniques (liver to muscle ratio or calculation of the decay rate of the T2 * signal). Since the initial publications at 1.5 Tesla, new technical innovations have emerged which can allow better quantification. Recently, the investigators have applied these innovations to Rennes and have validated (SURFER study) the possibility of making a quantification of iron and fat on two 3 Tesla devices with good results in a single apnea acquisition. But it is not uncommon to have, in a structure, different magnetic field devices, and it is important to ensure that the results are transposable. It is also crucial for multicentre or cohort studies to ensure consistency. It is therefore proposed to compare the results of two examinations at 1.5 and 3 Tesla obtained on the same day on a series of 80 patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with hepatic iron overload or steatosis | Experimental | Each patient (80) will have two MRI exams on the same day: one performed in common practice on a 1.5 Tesla device and the other on a 3 Tesla device. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 1,5 Tesla abdominal MRI | Device | Measurement of the fat and iron |
|
| Measure | Description | Time Frame |
|---|---|---|
| Study of the agreement of the measurement of the fat and iron obtained by MRI, based on our previous calibrations (MRQuantif software), on two MRI devices. | Bland and Altman method comparing the quantification of iron and liver fat provided by the two MRI devices in the same patient using the MRQuantif software developed by the imaging department of the University Hospital of Rennes :
| Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Study of the concordance of the estimation of the quantification of the iron and the hepatic fat provided by our method and those of the constructors | Concordance of the estimation of the quantification of the iron and the hepatic fat provided by our method and those of the constructors | Day 1 |
| Analysis of the repeatability of the measurement (two acquisitions for each study). |
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Inclusion Criteria:
Exclusion Criteria:
Related to MRI
Other criteria
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| Name | Affiliation | Role |
|---|---|---|
| Yves Gandon, MD, PhD | Rennes University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital St Vincent du Groupement des Hôpitaux de l'Institut Catholique de Lille | Lille | France | ||||
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| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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| 3 Tesla abdominal MRI | Device | Measurement of the fat and iron |
|
Intraclass correlation coefficients (ICCs) and Bland & Altmann between two acquisitions |
| Day 1 |
| Analysis of the intra or interobserver reproducibility (several analysis for a single acquisition). | Intraclass correlation coefficients (ICCs) and Bland & Altmann between two readers/readings | Day 1 |
| CHU de Rennes |
| Rennes |
| 35033 |
| France |