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| Name | Class |
|---|---|
| Spanish Clinical Research Network - SCReN | NETWORK |
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Objectives: To study the prognostic value of the evolution of diastolic function according to fluid balance in patients admitted to the ICU with a diagnosis of septic shock, in terms of mortality (ICU and hospital) and mortality at 90 days.
2.4. Secondary objectives: A) Incidence and reversibility of myocardial dysfunction (left ventricular systolic and diastolic) in septic shock.
B) Incidence and reversibility of diastolic dysfunction according to the echocardiographic criterion used.
C) Incidence and reversibility of right ventricular systolic dysfunction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal function | No systolic dysfunction No diastolic dysfunction No right ventricular dysfunction |
| |
| Left ventricular systolic dysfunction | Left ventricular ejection fraction < 50% |
| |
| Left ventricular diastolic dysfunction | Classification according to:
|
| |
| Right ventricular dysfunction | Tricuspid annulus plane systolic excursion < 17 cm |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Echocardiography | Diagnostic Test | Usual echocardiographic studies in patients suffering septic shock |
|
| Measure | Description | Time Frame |
|---|---|---|
| Mortality at 90 days | Dead at 90 days | 90 days |
| Measure | Description | Time Frame |
|---|---|---|
| ICU mortality | Dead in ICU | 90 days |
| In hospital mortality | Dead in hospital | 90 days |
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Inclusion Criteria:
Exclusion Criteria:
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Patients admitted to the ICU with diagnosis of septic shock, and stay longer than 48h
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Luis Zapata Fenor, MD PhD | Contact | 0034935537255 | LZapata@santpau.cat |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Verge de la Cinta | Recruiting | Tortosa | Tarragona | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28262372 | Background | Suarez JC, Lopez P, Mancebo J, Zapata L. Diastolic dysfunction in the critically ill patient. Response from the authors. Med Intensiva. 2017 Apr;41(3):198. doi: 10.1016/j.medin.2016.12.008. Epub 2017 Mar 3. No abstract available. English, Spanish. | |
| 22717694 | Background | Mahjoub Y, Benoit-Fallet H, Airapetian N, Lorne E, Levrard M, Seydi AA, Amennouche N, Slama M, Dupont H. Improvement of left ventricular relaxation as assessed by tissue Doppler imaging in fluid-responsive critically ill septic patients. Intensive Care Med. 2012 Sep;38(9):1461-70. doi: 10.1007/s00134-012-2618-9. Epub 2012 Jun 21. |
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| ID | Term |
|---|---|
| D012772 | Shock, Septic |
| ID | Term |
|---|---|
| D018805 | Sepsis |
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
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| ID | Term |
|---|---|
| D004452 | Echocardiography |
| ID | Term |
|---|---|
| D057791 | Cardiac Imaging Techniques |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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| Incidence of myocardial disfunction | According to the criteria specified at groups section | During the first 24 hours of ICU admission |
| Change in incidence of diastolic dysfunction | Change in incidence of diastolic dysfunction according to the different criteria used. | From first 24 hours of ICU admission until 48h, 72h and 7 days from admission |
| Hospital de la Santa Creu i Sant Pau | Not yet recruiting | Barcelona | 08025 | Spain |
|
| Hospital de la Santa Creu i Sant Pau | Recruiting | Barcelona | Spain |
|
| Hospital del Mar | Recruiting | Barcelona | Spain |
|
| Hospital del Vall d´Hebron | Recruiting | Barcelona | Spain |
|
| 27422899 | Background | Nagueh SF, Smiseth OA, Appleton CP, Byrd BF 3rd, Dokainish H, Edvardsen T, Flachskampf FA, Gillebert TC, Klein AL, Lancellotti P, Marino P, Oh JK, Alexandru Popescu B, Waggoner AD; Houston, Texas; Oslo, Norway; Phoenix, Arizona; Nashville, Tennessee; Hamilton, Ontario, Canada; Uppsala, Sweden; Ghent and Liege, Belgium; Cleveland, Ohio; Novara, Italy; Rochester, Minnesota; Bucharest, Romania; and St. Louis, Missouri. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Eur Heart J Cardiovasc Imaging. 2016 Dec;17(12):1321-1360. doi: 10.1093/ehjci/jew082. Epub 2016 Jul 15. No abstract available. |
| D010335 |
| Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012769 | Shock |
| D014463 | Ultrasonography |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |