Impact of Energy Drink Brands on Heart Rhythm

Impact of Energy Drink Brands on Heart Rhythm in Healthy Volunteers: A Randomized Controlled Trial

To assess the cardiac effects of energy drink brands in healthy volunteers

Energy drinks are widely available and globally consumed. There are many brands of energy drinks on the market, and there are differences in the ingredients included. Previous studies have tried to evaluate the safety of energy drinks and have demonstrated a signal for some electrocardiographic (ECG) and hemodynamic effects. However, product related differences need further exploration. This study is designed to assess the effects of 2 different energy drink products on heart rhythm and blood pressure in healthy subjects.

Inclusion Criteria:

• Healthy male or female adults 18 - 40 years old
• Participants must be willing to refrain from caffeine and alcohol use ≥48 hours prior to sessions on Day 1, 8, and 15

Exclusion Criteria:

• Presence of any known medical condition confirmed through participant interview
• QTc interval greater than 450 milliseconds (ms).
• Blood pressure greater than 140/90 mmHg.
• Current smokers
• Concurrent use of prescription, over-the-counter (OTC) or herbal supplements taken on a daily basis (except oral contraceptives).
• Pregnant or currently breast-feeding