Cognitive Intervention in Mild Cognitive Impairment With or Without White Matter Hyperintensities

Evaluation of Differential Effects of a Computer-based-cognitive Intervention on Cognition Among Elderly With Mild Cognitive Impairment With and Without White Matter Hyperintensities: A Comparative Study.

This is a non-pharmacological study evaluating the differential effects of a computerized cognitive stimulation program according to the existence or not of white matter hyperintensities in elderly with mild cognitive impairment.

White matter hyperintensities (WMH) are increasingly recognized as a factor determining the heterogeneity of Mild Cognitive Impairment (MCI) and have been associated to executive and processing speed impairment. Cognitive interventions in MCI remain quite limited for these MCI with vascular profile and studies often distinguish patients by clinical subtypes rather than brain profile before an intervention. Considering magnetic resonance imaging (MRI) data, this study investigated the effects of a computer-based cognitive stimulation (CCS) program on MCI with WMH compared to MCI without WMH.

Inclusion Criteria:

• Clinical diagnosis of Mild Cognitive Impairment
• With and without white matter hyperintensities
• MRI available or accept to perform one
• No engagement in other cognitive intervention program

Exclusion Criteria:

• Psychiatric and neurological disorders
• History of alcohol or other substance abuse
• Sensory and/or motor deficit affecting the use of a tablet