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| Name | Class |
|---|---|
| The Luhe Teaching Hospital of the Capital Medical University | OTHER |
| Beijing Anzhen Hospital | OTHER |
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The purpose of this study is to assess the safety and efficacy of low dosage of Terazosin in Carotid Artery Stenting
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| TZ group | Experimental | Treatment:Patients in this group received standard medical therapy and Terazosin (TZ) treatment. Drug: TZ 0.5mg once a day for 3-7 days before carotid artery stenting to 30 days later. Procedure: Carotid Artery Stenting |
|
| control group | Other | Treatment: Patients in this group received standard medical therapy alone. Procedure: Carotid Artery Stenting |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Terazosin | Drug | TZ 0.5mg once a day for 3-7 days before carotid artery stenting to 30 days later. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Participants who got New DWI Lesions (MRI) | Patients who got new ischemic lesions as defined by DWI MRI within 48 hours after carotid artery stenting | Within 48 hours after carotid artery stenting |
| Measure | Description | Time Frame |
|---|---|---|
| Number of New DWI Lesions (MRI) | Number of new ischemic lesions as defined by DWI MRI within 48 hours after carotid artery stenting | Within 48 hours after carotid artery stenting |
| Volume of New DWI Lesions (MRI) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xunming Ji, MD PhD | Contact | +86-83198952 | jixunming@vip.163.com; jiangfanghappy@126.com | |
| Fang Jiang, MD | Contact | jiangfanghappy@126.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Anzhen Hospital | Recruiting | Beijing | Beijing Municipality | 100029 | China |
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| ID | Term |
|---|---|
| D016893 | Carotid Stenosis |
| ID | Term |
|---|---|
| D002340 | Carotid Artery Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| ID | Term |
|---|---|
| C041226 | Terazosin |
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| Carotid artery stenting | Procedure | Carotid artery stenting is an alternative treatment of carotid artery stenosis, which would be performed by experienced neuroradiologist according to the latest guideline from American Heart Association and American Stroke Association. |
|
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Volume of new ischemic lesions as defined by DWI MRI within 48 hours after carotid artery stenting
| Within 48 hours after carotid artery stenting |
| Number of patients with New DWI Lesions (MRI) diameter greater than 5mm | Patients who got new ischemic lesions diameter greater than 5mm as defined by DWI MRI within 48 hours carotid artery stenting | Within 48 hours after carotid artery stenting |
| Number of Patients with Cerebrovascular Events, Cardiovascular Events or Death. | Cerebrovascular events included ischemic stroke, transient ischemic attack (TIA), cerebral hemorrhage and hyperperfusion syndrome. Cardiovascular events included angina and myocardial infarction. Death included any reason caused death. | From baseline to 30 days after treatment |
| Laboratory Examination | Laboratory Examination before and post-treatment | Before and 24 hours after carotid artery stenting |
| Number of Patients underwent hypertensive treatment due to post-procedure hypotention | Number of Patients underwent hypertensive treatment due to post-procedure hypotention | 0-7 days or discharge which comes early |
| Number of Patients with Any Side Events | Any side events caused by TZ, regular treatment or CAS | From baseline to 30 days after treatment |
| Mortality | Any cause of death | From baseline to 30 days after treatment |
| The Luhe Teaching Hospital of the Capital Medical University | Recruiting | Beijing | Beijing Municipality | 101100 | China |
|
| D009422 | Nervous System Diseases |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |