The aim of this study is to evaluate the feasibility of hypofractionated radiation therapy and concomitant chemotherapy with cisplatin for locally advanced head and neck cancer in a high volume brazilian center.

To evaluate if concomitant cisplatin and hypofractionated radiation therapy wold be feasible in a brazilian population.

Patients eligibility criteria:

older than 18 years old Biopsy proven squamous cell carcinoma of oropharynx, larynx and hypopharynx. Stage III an IV, with no distant metastasis. ECOG performance status 0-2. Adequate renal and liver function. Good status for radical treatment

Treatment considered feasible if:

1. Patient receive at least 90% of radiation dose (18 of 20 fractions of 275cGy)
2. Patients receive at least 3 of 4 weekly cycles of cisplatin (35mg/m2)
3. Treatment length up to 35 days.
4. Grade 4 toxicity lower than 25%

Inclusion Criteria:

• Biopsy proven squamous cell carcinoma of oropharynx, larynx and hypopharynx.
• Stage III an IV, with no distant metastasis.
• ECOG performance status 0-2.
• Adequate renal and liver function.
• Good status for radical treatment

Exclusion Criteria:

• Other oncologic treatment before
• Distant metastasis
• History of previous malignancy