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| ID | Type | Description | Link |
|---|---|---|---|
| 1K24DK105989 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| The Boston Foundation | UNKNOWN |
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | NIH |
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The First 1000 Days (conception to age 2) is a crucial period for the development and prevention of obesity and its adverse consequences in mother-child pairs and their families. The overall aim of the First 1000 Days program is to work across early-life systems to prevent obesity, promote healthy routines and behaviors, address social determinants of health, and reduce health disparities among vulnerable children and families at community health centers in the Boston, MA area.
The study aims to simultaneously implement and evaluate an obesity prevention program across early life systems to reduce the prevalence of obesity risk factors within racial/ethnic minority families, close the gap in maternal-child health disparities, and assess and address social determinants of health.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| First 1,000 Days Program | Experimental |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| First 1,000 Days Program Site | Behavioral | Program components will include 1) Enhancements to and improved use of electronic health records to improve the quality of preventive services and screening for social determinants of health; 2) Staff and provider training; 3) Consistent behavior change messaging; 4) Patient education via print materials, text messaging and short videos; and 5) Strengthening the integration of clinical and public health services to support behavior change and address social determinants of health. |
| Measure | Description | Time Frame |
|---|---|---|
| Maternal Gestational Weight Gain | Weight gained during pregnancy | First prenatal care visit to 36 weeks gestation |
| Infant Weight-for-Length Z-Score | Age- and sex-specific weight-for-length z-score | Child age 6 months |
| Infant Weight-for-Length Z-score | Age- and sex-specific weight-for-length z-score | Child age 12 months |
| Infant Weight-for-Length Z-Score | Age- and sex-specific weight-for-length z-score | Child age 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change from 1st trimester maternal diet to 3rd trimester | Average weekly intake | An average of 18 weeks (1st trimester to 3rd trimester) |
| Change from 1st trimester maternal physical activity to 3rd trimester |
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Inclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Elsie Taveras, MD, MPH | Massachusetts General Hospital | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33294495 | Background | Neri Mini F, Saltzman JA, Simione M, Luo M, Perkins ME, Roche B, Blake-Lamb T, Kotelchuck M, Arauz-Boudreau A, Davison K, Taveras EM. Expectant Fathers' Social Determinants of Health in Early Pregnancy. Glob Pediatr Health. 2020 Nov 27;7:2333794X20975628. doi: 10.1177/2333794X20975628. eCollection 2020. | |
| 35321774 | Background | Cheng ER, Luo M, Perkins M, Blake-Lamb T, Kotelchuck M, Arauz Boudreau A, Taveras EM. Household food insecurity is associated with obesogenic health behaviours among a low-income cohort of pregnant women in Boston, MA. Public Health Nutr. 2023 May;26(5):943-951. doi: 10.1017/S1368980022000714. Epub 2022 Mar 24. |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| D009043 | Motor Activity |
| D005247 | Feeding Behavior |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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The First 1,000 Days program is a systems-level program that will reach all expectant mothers and families with 0-2 year olds receiving care at Boston-area community health centers. Mothers and infants at two similar non-intervention Boston-area health centers will be used as a comparison sample. Maternal and infant obesity-related clinical information is routinely recorded during patient visits in the EHR used at both the intervention and comparison sites. Sample size enrollment reflects maternal-infant dyads.
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|
Days per week physically active for at least 30 minutes per day
| An average of 18 weeks (1st trimester to 3rd trimester) |
| Change from 1st trimester maternal sleep duration to 3rd trimester | Average hours per day | An average of 18 weeks (1st trimester to 3rd trimester) |
| Change from 1st trimester maternal sedentary time to 3rd trimester | Hours per day of screentime | An average of 18 weeks (1st trimester to 3rd trimester) |
| Change from 1st trimester depression to 3rd trimester | Edinburgh Postnatal Depression Scale | An average of 18 weeks (1st trimester to 3rd trimester) |
| Change from 1st trimester maternal food insecurity to 3rd trimester | 2-question validated scale | An average of 18 weeks (1st trimester to 3rd trimester) |
| Change from 1st trimester maternal housing insecurity to 3rd trimester | 2-question validated scale | An average of 18 weeks (1st trimester to 3rd trimester) |
| Change from 1st trimester pregnancy-related anxiety to 3rd trimester | 5-question validated scale | An average of 18 weeks (1st trimester to 3rd trimester) |
| Change from 1st trimester enrollment in food assistance programs to 3rd trimester | Yes/No response options for program enrollment in WIC and SNAP | An average of 18 weeks (1st trimester to 3rd trimester) |
| 33046003 | Background | Cruz-Bendezu AM, Lovell GV, Roche B, Perkins M, Blake-Lamb TL, Taveras EM, Simione M. Psychosocial status and prenatal care of unintended pregnancies among low-income women. BMC Pregnancy Childbirth. 2020 Oct 12;20(1):615. doi: 10.1186/s12884-020-03302-2. |
| 29225195 | Background | Blake-Lamb T, Boudreau AA, Matathia S, Tiburcio E, Perkins ME, Roche B, Kotelchuck M, Shtasel D, Price SN, Taveras EM. Strengthening integration of clinical and public health systems to prevent maternal-child obesity in the First 1,000Days: A Collective Impact approach. Contemp Clin Trials. 2018 Feb;65:46-52. doi: 10.1016/j.cct.2017.12.001. Epub 2017 Dec 7. |
| 34706698 | Background | Simione M, Moreno-Galarraga L, Perkins M, Price SN, Luo M, Kotelchuck M, Blake-Lamb TL, Taveras EM. Effects of the First 1000 Days Program, a systems-change intervention, on obesity risk factors during pregnancy. BMC Pregnancy Childbirth. 2021 Oct 27;21(1):729. doi: 10.1186/s12884-021-04210-9. |
| 32282612 | Result | Blake-Lamb T, Boudreau AA, Matathia S, Perkins ME, Roche B, Cheng ER, Kotelchuck M, Shtasel D, Taveras EM. Association of the First 1,000 Days Systems-Change Intervention on Maternal Gestational Weight Gain. Obstet Gynecol. 2020 May;135(5):1047-1057. doi: 10.1097/AOG.0000000000003752. |
| 34326179 | Result | Taveras EM, Perkins ME, Boudreau AA, Blake-Lamb T, Matathia S, Kotelchuck M, Luo M, Price SN, Roche B, Cheng ER. Twelve-Month Outcomes of the First 1000 Days Program on Infant Weight Status. Pediatrics. 2021 Aug;148(2):e2020046706. doi: 10.1542/peds.2020-046706. |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001519 | Behavior |
| D001522 | Behavior, Animal |