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| Name | Class |
|---|---|
| Beijing 302 Hospital | OTHER |
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Nonalcoholic steatohepatitis (NASH) is now recognised as an increasing clinical problem in children. Steatosis without significant liver cell injury or fibrosis is the most common form of nonalcoholic fatty liver disease (NAFLD) in both adults and children. Studies in the adult population have variably suggested that steatosis is a benign nonprogressive condition and NASH is recognised as a potentially serious condition with significantly risk of morbidity and mortality.
A growing body of evidence suggests that children with NASH frequently show histopathological features that differ from those of adults. The prevalence of this pattern in a wide range of paediatric cases as well as other histopathological lesions and their relevance and prognostic significance in children with NAFLD remains to be determined. Thus the investigators would like to conduct a study of biopsies and clinical information to document the histological features of paediatric NAFLD, to explore the natural history of paediatric NAFLD, and to determine the frequency and prognostic value of these features.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | There will be no specific intervention to these paediatric NASH patient |
| Measure | Description | Time Frame |
|---|---|---|
| Liver related death | Whether the patients die from liver-related causes | Through study completion, an average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Complications of cirrhosis | Whether the complication of cirrhosis i.e. ascites, hepatic encephalopathy, variceal bleeding occur during the follow-up | Through study completion, an average of 1 year |
| Liver biopsy |
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Inclusion Criteria:
Exclusion Criteria:
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Children with NAFLD who attended the Children's Liver Disease Center, 302 Hospital, Beijing, China will be identified and recruited. Participants met above inclusion and exclusion criteria will be invited to the study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| George Lau, MD, PhD | Contact | 852-28613777 | gkklau@hnhmgl.com | |
| Yudong Wang, MD, PhD | Contact | 852-28184300 | danny.wang@hnhmgl.com |
| Name | Affiliation | Role |
|---|---|---|
| George Lau, MD, PhD | Humanity and Health Medical Centre | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Children's Liver Disease Center, 302 Hospital | Recruiting | Beijing | China |
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| ID | Term |
|---|---|
| D065626 | Non-alcoholic Fatty Liver Disease |
| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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Liver-biopsy will be collected and to be used as the diagnosis of NASH.
| Through study completion, an average of 2 year |
| Liver transplant | Whether the patients have liver transplant during the follow-up | Through study completion, an average of 1 year |