Prospective observational study in which FXIII levels and coagulation tests and cicatrization are measured during the 30 days after the thermal trauma.

This is a prospective observational pilot study in which the levels of FXIII and coagulation, anticoagulation, fibrinolysis, endothelial tissue damage and cicatrization are at the arrival of the patient to hospital, 24 hours before the first surgical intervention, 24h After the first surgical intervention, at 7 days after the first intervention and at 30 days after the thermal trauma, in this moment the healing will also be evaluated. All burn patients who meet the proposed inclusion criteria will be included and entered into the Burn Unit of the Vall d'Hebron University Hospital from the start of the study until reaching a minimum of 20 cases or a temporary term of 2 years.

Inclusion Criteria:

• Burned patients with a burned body surface of 20% or more
• Over 18 years of age

Exclusion Criteria:

• ABSI (Abbreviated Burns Severity Index) greater than or equal to 12
• Associated polytrauma
• Coagulation deficit previously known
• Treatment with anticoagulants
• Electrocution burns
• Admission into the unit after hour 6 after thermal trauma
• The refusal of the patient, familiar or responsible to participate in the study

Burned patients over 18 years of age with a burned body surface of 20% or more admitted to the burn unit of the Vall d'Hebron University Hospital from the start of the study to the end of the study with surgical burns ( Second grade or third grade) and for whom informed consent has been obtained