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This is a registry study in adult patients with newly diagnosed or refractory/relapsed acute myeloid leukemia.
Investigator's sites: 60 sites in Germany.
Primary objectives:
see brief summary
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| Measure | Description | Time Frame |
|---|---|---|
| Epidemiological parameters | Epidemiological parameters | 10 years |
| Relapse free survival (RFS) | Relapse free survival | 10 years |
| Time to relapse (TTR), | Time to relapse (TTR), | 10 years |
| Overall Survival (OS) | Overall Survival (OS) | 10 years |
| cumulative incidence of relapse (CIR) | cumulative incidence of relapse (CIR) | 10 years |
| Measure | Description | Time Frame |
|---|---|---|
| Complete Remission (CR) | Complete Remission | yearly follow up 10 years |
| Treatment related mortality (TRM) | Treatment related mortality |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with newly-diagnosed AML, including acute promyelocytic leukemia (APL)
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Christoph Röllig, Prof. Dr. | Contact | christoph.roellig@uniklinikum-dresden.de |
| Name | Affiliation | Role |
|---|---|---|
| Christoph Röllig, Prof. Dr. | Universitätsklinikum Carl Gustav Carus | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Klinikum Mittelbaden | Recruiting | Baden-Baden | Baden-Wurttemberg | 76532 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36167894 | Derived | Hanoun M, Ruhnke L, Kramer M, Hanoun C, Schafer-Eckart K, Steffen B, Sauer T, Krause SW, Schliemann C, Mikesch JH, Kaufmann M, Hanel M, Jost E, Brummendorf TH, Fransecky L, Kraus S, Einsele H, Niemann D, Neubauer A, Kullmer J, Seggewiss-Bernhard R, Gorner M, Held G, Kaiser U, Scholl S, Hochhaus A, Reinhardt HC, Platzbecker U, Baldus CD, Muller-Tidow C, Bornhauser M, Serve H, Rollig C; Study Alliance Leukemia (SAL). Intensified cytarabine dose during consolidation in adult AML patients under 65 years is not associated with survival benefit: real-world data from the German SAL-AML registry. J Cancer Res Clin Oncol. 2023 Jul;149(8):4611-4621. doi: 10.1007/s00432-022-04356-9. Epub 2022 Sep 28. | |
| 36064577 |
| Label | URL |
|---|---|
| Website study alliance leukemia | View source |
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bone marrow and peripher blood
| yearly follow up 10 years |
| Therapy-associated morbidity | grade IV toxicities | yearly follow up 10 years |
| Recording and evaluating the quality of therapy and diagnosis | Recording and evaluating the quality of therapy and diagnosis | 10 years |
| Validation of published prognostic factors at the registry cohort and the search for new possible prognostic factors | Validation of published prognostic factors at the registry cohort and the search for new possible prognostic factors | 10 years |
| Recording and describing new forms of therapy and new supportive measures | Recording and describing new forms of therapy and new supportive measures | 10 years |
| Universtitätsklinikum Heidelberg | Recruiting | Heidelberg | Baden-Wurttemberg | 69120 | Germany |
|
| Klinikum Mannheim GmbH | Recruiting | Mannheim | Baden-Wurttemberg | 68167 | Germany |
|
| Diakonie-Klinikum | Recruiting | Schwäbisch Hall | Baden-Wurttemberg | 74523 | Germany |
|
| Kliniken Sindelfingen-Böblingen gGmbH | Recruiting | Sindelfingen | Baden-Wurttemberg | 71065 | Germany |
|
| Robert-Bosch-Krankenhaus GmbH | Recruiting | Stuttgart | Baden-Wurttemberg | 70376 | Germany |
|
| Rems-Murr-Klinikum Winnenden | Recruiting | Winnenden | Baden-Wurttemberg | 71364 | Germany |
|
| Klinikum Augsburg | Recruiting | Augsburg | Bavaria | 86156 | Germany |
|
| Sozialstiftung Bamberg | Recruiting | Bamberg | Bavaria | 96049 | Germany |
|
| Klinikum Bayreuth GmbH | Recruiting | Bayreuth | Bavaria | 95445 | Germany |
|
| MVZ Klinikum Coburg GmbH | Recruiting | Coburg | Bavaria | 96450 | Germany |
|
| ONKO Medeor Onkologische Zentren | Recruiting | Donauwörth | Bavaria | 86609 | Germany |
|
| Universitätsklinikum Erlangen | Recruiting | Erlangen | Bavaria | 91054 | Germany |
|
| Klinikum Nürnberg | Recruiting | Nuremberg | Bavaria | 90419 | Germany |
|
| Universitätsklinikum Würzburg | Recruiting | Würzburg | Bavaria | 97080 | Germany |
|
| Carl-Thiem-Klinikum Cottbus gGmbH | Recruiting | Cottbus | Brandenburg | 03048 | Germany |
|
| Klinikum Frankfurt (Oder) GmbH | Recruiting | Frankfurt (Oder) | Brandenburg | 15236 | Germany |
|
| Universitätsklinikum Frankfurt | Recruiting | Frankfurt am Main | Hesse | 60590 | Germany |
|
| Klinikum Fulda / MVZ Osthessen GmbH | Recruiting | Fulda | Hesse | 36043 | Germany |
|
| Universitätsklinikum Gießen und Marburg | Recruiting | Marburg | Hesse | 35033 | Germany |
|
| Dr. Horst Schmidt Kliniken GmbH | Recruiting | Wiesbaden | Hesse | 65199 | Germany |
|
| St. Bernward Krankenhaus Hildesheim | Recruiting | Hildesheim | Lower Saxony | 31134 | Germany |
|
| Agaplesion Diakonieklinikum Rotenburg | Recruiting | Rotenburg (Wümme) | Lower Saxony | 27956 | Germany |
|
| Klinikum Wolfsburg | Recruiting | Wolfsburg | Lower Saxony | 38440 | Germany |
|
| Diakonie Klinikum Dietrich Bonhoeffer | Recruiting | Neubrandenburg | Mecklenburg-Vorpommern | 17036 | Germany |
|
| Klinikum Südstadt Rostock | Recruiting | Rostock | Mecklenburg-Vorpommern | 18059 | Germany |
|
| HELIOS Klinikum Schwerin | Recruiting | Schwerin | Mecklenburg-Vorpommern | 10955 | Germany |
| Marien Kliniken, St. Marien-Krankenhaus | Recruiting | Siegen | Nordhein-Westfalen | 57072 | Germany |
|
| Universitätsklinikum Aachen | Recruiting | Aachen | North Rhine-Westphalia | 52074 | Germany |
|
| Städt. Kliniken Bielefeld gem. GmbH - Klinikum Mitte | Recruiting | Bielefeld | North Rhine-Westphalia | 33604 | Germany |
|
| Augusta Kranken Anstalt Bochum | Recruiting | Bochum | North Rhine-Westphalia | 44791 | Germany |
|
| Klinikum der Universität zu Köln | Recruiting | Cologne | North Rhine-Westphalia | 50937 | Germany |
|
| Helios Klinikum Duisburg | Recruiting | Duisburg | North Rhine-Westphalia | 47166 | Germany |
|
| Helios Klinikum Duisburg | Recruiting | Duisburg | North Rhine-Westphalia | 47228 | Germany |
|
| Krankenhaus Düren gGmbH | Recruiting | Düren | North Rhine-Westphalia | 52351 | Germany |
|
| Universitätsklinikum Düsseldorf | Recruiting | Düsseldorf | North Rhine-Westphalia | 40225 | Germany |
|
| Alfried Krupp Krankenhaus Rüttenscheid | Recruiting | Essen | North Rhine-Westphalia | 45131 | Germany |
|
| Universitätsklinikum Essen | Recruiting | Essen | North Rhine-Westphalia | 45747 | Germany |
|
| Klinikum Gütersloh | Recruiting | Gütersloh | North Rhine-Westphalia | 33332 | Germany |
|
| St. Barbara-Klinik Hamm GmbH | Recruiting | Hamm | North Rhine-Westphalia | 59075 | Germany |
|
| Universitätsklinikum Münster | Recruiting | Münster | North Rhine-Westphalia | 48149 | Germany |
|
| Diakonie Klinikum GmbH Jung-Stilling-Krankenhaus | Recruiting | Siegen | North Rhine-Westphalia | 57074 | Germany |
|
| Stiftungsklinikum Mittelrhein GmbH | Recruiting | Koblenz | Rhineland-Palatinate | 56068 | Germany |
|
| Klinikum Chemnitz gGmbH | Recruiting | Chemnitz | Saxony | 09113 | Germany |
|
| Universitätsklinikum Carl Gustav Carus | Recruiting | Dresden | Saxony | 01307 | Germany |
|
| Universitätsklinikum Leipzig | Recruiting | Leipzig | Saxony | 04103 | Germany |
|
| Klinikum St. Georg gGmbH | Recruiting | Leipzig | Saxony | 04129 | Germany |
|
| Elblandkliniken Stiftung & Co.KG | Recruiting | Riesa | Saxony | 01589 | Germany |
|
| Heinrich-Braun-Klinikum gGmbH | Recruiting | Zwickau | Saxony | 08060 | Germany |
|
| Krankenhaus Martha-Maria Halle-Dölau | Recruiting | Halle | Saxony-Anhalt | 06120 | Germany |
|
| Universitätsklinikum Halle (Saale) | Recruiting | Halle | Saxony-Anhalt | 06120 | Germany |
|
| Johanniter-Krankenhaus Genthin-Stendal | Recruiting | Stendal | Saxony-Anhalt | 39576 | Germany |
|
| Universitätsklinikum Schleswig-Holstein | Recruiting | Kiel | Schleswig-Holstein | 24105 | Germany |
|
| Städtisches Krankenhaus Kiel GmbH | Recruiting | Kiel | Schleswig-Holstein | 24116 | Germany |
|
| Alexianer St. Hedwig-Krankenhaus | Recruiting | Berlin | State of Berlin | 10115 | Germany |
|
| Helios Klinikum Berlin-Buch | Recruiting | Berlin | State of Berlin | 13125 | Germany |
|
| Klinikum Altenburger Land GmbH | Recruiting | Altenburg | Thuringia | 04600 | Germany |
|
| Helios Klinikum Erfurt | Recruiting | Erfurt | Thuringia | 99089 | Germany |
|
| Universitätsklinikum Jena | Recruiting | Jena | Thuringia | 07740 | Germany |
|
| Ev. Diakonie-Krankenhaus gemeinn. GmbH Bremen | Recruiting | Bremen | 28239 | Germany |
|
| Derived |
| Kunadt D, Stasik S, Metzeler KH, Rollig C, Schliemann C, Greif PA, Spiekermann K, Rothenberg-Thurley M, Krug U, Braess J, Kramer A, Hochhaus A, Scholl S, Hilgendorf I, Brummendorf TH, Jost E, Steffen B, Bug G, Einsele H, Gorlich D, Sauerland C, Schafer-Eckart K, Krause SW, Hanel M, Hanoun M, Kaufmann M, Wormann B, Kramer M, Sockel K, Egger-Heidrich K, Herold T, Ehninger G, Burchert A, Platzbecker U, Berdel WE, Muller-Tidow C, Hiddemann W, Serve H, Stelljes M, Baldus CD, Neubauer A, Schetelig J, Thiede C, Bornhauser M, Middeke JM, Stolzel F; A. M. L. Cooperative Group (AMLCG), Study Alliance Leukemia (SAL). Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation. J Hematol Oncol. 2022 Sep 5;15(1):126. doi: 10.1186/s13045-022-01339-8. |
| 32496541 | Derived | Rollig C, Kramer M, Schliemann C, Mikesch JH, Steffen B, Kramer A, Noppeney R, Schafer-Eckart K, Krause SW, Hanel M, Herbst R, Kunzmann V, Einsele H, Jost E, Brummendorf TH, Scholl S, Hochhaus A, Neubauer A, Sohlbach K, Fransecky L, Kaufmann M, Niemann D, Schaich M, Frickhofen N, Kiani A, Heits F, Krumpelmann U, Kaiser U, Kullmer J, Wass M, Stolzel F, von Bonin M, Middeke JM, Thiede C, Schetelig J, Berdel WE, Ehninger G, Baldus CD, Muller-Tidow C, Platzbecker U, Serve H, Bornhauser M. Does time from diagnosis to treatment affect the prognosis of patients with newly diagnosed acute myeloid leukemia? Blood. 2020 Aug 13;136(7):823-830. doi: 10.1182/blood.2019004583. |
| ID | Term |
|---|---|
| D015470 | Leukemia, Myeloid, Acute |
| ID | Term |
|---|---|
| D007951 | Leukemia, Myeloid |
| D007938 | Leukemia |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
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