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To investigate the influence of stellate ganglion block on tourniquet response during surgery in patients undergoing elective lower limb Department of orthopedics.
Select elective general anesthesia in 100 cases of lower extremity Department of orthopedics surgery patients were randomly divided into SGB group and control group, SGB group received anesthesia before the right stellate ganglion block intervention, the control group underwent right deltoid muscle injection, changes in hemodynamics in two groups were recorded in heart rate, blood pressure, and before anesthesia, after intubation 3min 1H, a tourniquet, tourniquet release before and after tourniquet release 3min, 30min, changes in blood physiological analysis. The effect of stellate ganglion block on tourniquet response during perioperative period was observed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Stellate ganglion block | Active Comparator | Stellate ganglion block |
|
| control group | Placebo Comparator | Deltoid muscle injection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stellate ganglion block | Procedure | Stellate ganglion block with 1% lidocaine 10ml |
|
| Measure | Description | Time Frame |
|---|---|---|
| blood pressure | mmHg | 2 hours in perioperative period |
| heart rate | bpm | 2 hours in perioperative period |
| Lac | blood gas analysis mmol/L | One minute after the radial artery puncture, the tourniquet was applied for 1 hours and the tourniquet was released 3 minutes after the tourniquet release 30 minutes |
| cortisol | ELISA ng/ml | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet |
| norepinephrine | ELISA nmol/L | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet |
n nitrate reductase method μmol/L | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet | |
| ET-1 | ELISA ng/L | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet |
| Measure | Description | Time Frame |
|---|---|---|
| Complication of puncture | bleeding、nerve injury、 | 2 hours in perioperative period |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tie Xu, MD | Contact | 13952110889 | xutie889@163.com | |
| Shuangshuang Meng, bachelor | Contact | 15862167035 | mengss@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Tie Xu, MD | The Affiliated Hospital of Xuzhou Medical University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Affiliated Hospital of Xuzhou Medical University | Recruiting | Xuzhou | Jiangsu | 221000 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 15101858 | Background | Arai YC, Ogata J, Matsumoto Y, Yonemura H, Kido K, Uchida T, Ueda W. Preoperative stellate ganglion blockade prevents tourniquet-induced hypertension during general anesthesia. Acta Anaesthesiol Scand. 2004 May;48(5):613-8. doi: 10.1111/j.0001-5172.2004.00389.x. |
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IPD will be available when this trial is finished and the article have been published.
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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| control group | Procedure | Deltoid muscle injection with 1% lidocaine 10ml |
|
| MDA | ELISA nmol/ml | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet |
| SOD | ELISA μg/L | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet |
| IL-6 | ELISA pg/ml | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet |
| cTn-T | ELISA μg/L | One minute after the radial artery puncture, one minute after intubation, tourniquet application 1 hour, one minute before tourniquet, loose after a tourniquet for 3 minutes, 30 minutes after a tourniquet |
| postoperative pain | VAS score | hour 1、hour 6、hour 24、hour 48 after operation |
| D008722 | Methods |