To assess the efficacy of Left Ventricular Hypertrophy (LVH) reduction and 24-hour blood pressure control of Valsartan 80mg or Nebivolol/Valsartan 5/80mg once daily as replacement therapy for currently treated or untreated hypertensive patients with LVH not at BP goal.

The potential benefits of blood pressure reduction have been demonstrated in numerous large clinical trials. The most recent is the SPRINT Trial demonstrating that lower blood pressure goals can be achieved and are associated with a significant decrease in morbidity and mortality. The latest NHANES 2012 data reveal that less than 50% of patients that are aware of the elevated blood pressure and are being treated achieve blood pressure control. Treatment of hypertension in many patients (>70%) require treatment with more than one drug, increasing the likelihood of non-compliance and not achieving blood pressure goal. JNC 8 recommends the utilizing of combination therapy both for Stage I and Stage II Hypertensive patients.

Objectives of the study to assess the efficacy of LVH reduction and 24-hour blood pressure control of Valsartan 80mg and Nebivolol/Valsartan 5/80mg, once daily for the treatment of currently treated hypertensive patients with LVH.

The study will evaluate LVH reduction at 4 and 8 weeks as well as change from baseline in mean 24 hour ABPM SBP after 4 and 8 weeks of treatment with valsartan 80mg or nebivolol/valsartan 5/80mg

Inclusion Criteria:

1. Capable of reading, comprehending the consent process and providing written informed consent to participate in the study.
2. Male or female ≥ 18 years of age who are either newly diagnosed with HTN or who are currently being treated.
3. Patients must have a mean cuff sitting diastolic blood pressure cuff (DBP) > 90 mmHg and <105 mmHg (< 100 mmHg on prior treatment) and mean cuff sitting systolic blood pressure (SBP) <160 mmHg, at two consecutive qualifying visits during the placebo run in period.
4. Arm circumference < 45cm.
5. Compliance with single blind placebo capsules between V1 to 4 or 4X of 80-120%.
6. Women may be enrolled if the following criteria are met:

1.- Have a negative serum pregnancy test at screening 2.- Are not breastfeeding 3.- Do not plan to become pregnant during the study 4.- Have had a hysterectomy or tubal ligation at least 6 months prior to signing the informed consent form or 5.- Have been postmenopausal for at least 1 year or 6. - If they are of childbearing potential and will practice one of the following methods of birth control throughout the study: oral, patch, injectable, or implantable hormone contraception, intrauterine device, diaphragm plus spermicide or female condom plus spermicide. Abstinence, partner's vasectomy are not acceptable methods of contraception.

7. Diagnosis of Left Ventricular Hypertrophy (LVH).

Exclusion Criteria:

1. Known allergy or hypersensitivity to Beta-Blockers.

2. Known allergy or hypersensitivity to Angiotensin II Receptor Blockers.

3. Patients with severe hypertension (mean seated cuff DBP>115 mmHg or mean seated SBP> 180mmHg) or any form of secondary hypertension.

4. Patients within the past 6 months with a history of hypertensive encephalopathy, stroke or transient ischemic attack.

5. Patients within the last 6 months with a history of myocardial infarction, percutaneous transluminal coronary revascularization, coronary bypass graft, valvular surgery or unstable angina.

6. Patients with evidence of resting bradycardia (<50 bpm) via palpation.

7. Patients with a history of heart block greater than First Degree Sino-atrial Block. Wolff-Parkinson-White Syndrome, Sick Sinus Syndrome, Atrial Fibrillation, Atrial Flutter, Congestive Heart Failure, or other manifestations of clinically significant cardiac valvular disease.

8. Patients with hemodynamically significant cardiac valvular disease.

9. Patients with evidence of significant chronic renal impairment as indicated by a serum creatinine of > 2.5mg/dL.

10. Patients with evidence of liver disease as indicated by AST (SGOT) or ALT (SGPT) > 2.5 times or total bilirubin > 1.5 times, the upper limit of the laboratory normal range.

11. Patients who demonstrate other laboratory test values deviating from the normal range which are considered to be clinically significant by the investigator.

12. Patient with a history or presence of gastrointestinal disease which may interfere with drug absorption.

13. Patients with insulin and non-insulin dependent diabetes mellitus not controlled on diet, insulin, or oral hypoglycemics as defined by a HgA1c >10.

14. Severe psychological or emotional condition which may interfere with participation in the study.

15. History of or current use of illicit drugs or alcohol abuse.

16. Participation in a clinical trial and taking any investigational drug within 30 days prior to enrolling into the study (Screening Visit).

17. A physical condition that would limit accurate BP measurement.

18. Inability to swallow a tablet or capsule.

19. History of moderate or severe asthma or COPD.

20. Any other medical condition which, in the Investigator's opinion, may render the patient unable to complete the study or which would interfere with optimal participation in the study or produce significant risk to the patient.

21. Patients taking more than two blood pressure medications

22. Patients currently taking a beta blocker

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