Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery | NCT03180268 | Trialant

Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery | NCT03180268 | Trialant

Official Title: Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma
Brief Summary: This randomized phase III trial studies how well radiation therapy works compared with observation in treating patients with newly diagnosed grade II meningioma that has been completely removed by surgery. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors.
Detailed Description: PRIMARY OBJECTIVE:

I. To determine the extent of clinical benefit of the addition of adjuvant radiotherapy (RT) to gross total resection (GTR) for patients with newly diagnosed World Health Organization (WHO) grade II meningioma.

SECONDARY OBJECTIVES:

I. Overall survival (OS). II. Disease-specific survival (DSS). III. Toxicity (grade 3+, exclusive of expected alopecia). IV. Neurocognitive function (NCF). V. Patient reported outcomes (PRO) measurements. VI. Adherence to protocol-specific target and normal tissue parameters. VII. Concordance measurements of central versus parent-institution pathology. VIII. Assessment of pHH3 mitotic index and its correlation with progression-free survival (PFS) and OS.

IX. Validation of the prognostic value of a 34-gene expression biomarker. X. Validation of the predictive value of a 34-gene expression biomarker in predicting the benefit of radiotherapy.

XI. Tissue and specimen collection for future translational research.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I: Patients undergo observation. Additionally, patients undergo magnetic resonance imaging (MRI) and blood collection throughout the study.

ARM II: Patients undergo intensity-modulated radiation therapy (IMRT) or proton beam radiation therapy 5 days a week over 6.5-7 weeks for a total of 33 fractions in the absence of disease progression or unacceptable toxicity. Additionally, patients undergo MRI and blood collection throughout the study.

After completion of study treatment, patients are followed up at 3, 6, and 12 months, every 6 months for year 2 and 3, then yearly for 10 years.

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

PRIOR TO STEP 1 REGISTRATION:

The patient must have a newly diagnosed unifocal intracranial meningioma, gross totally resected, and histologically confirmed as WHO grade II based upon pathology findings at the enrolling institution. WHO grade will be assigned according to WHO 2016 criteria

Gross total resection (GTR) will be interpreted as modified Simpson grade 1-3 without gross residual dural-based or extradural tumor. GTR must be confirmed both by modified Simpson grade and by post-operative magnetic resonance imaging (MRI) findings. The modified Simpson grade can be inferred from the operative report (surgeon does not need to explicitly describe the Simpson grade for the purposes of eligibility)

Step 1 registration must occur within 180 days of the initial surgery; this will provide sufficient time for post-operative imaging confirmation of resection extent after resolution of operative changes. Moreover, it will permit additional surgery if needed to achieve a GTR. Within this 180 day interval, a second surgery is permitted in order to achieve GTR, but even with a second surgery, Step 1 registration must occur within 180 days of the initial resection

GTR must be confirmed on post-operative imaging following the most recent surgery. For protocol enrollment, the assessment of GTR will be made at each site. However, submission of both pre-operative and post-operative MRIs is required for patients. If a second surgery is performed, submission of post-operative MRI is required and pre-operative MRI is required only if obtained. All sequences obtained in the pre- and post-operative MR imaging are to be submitted to National Radiology Group (NRG) Oncology for study registration. The post-operative MRI must be completed within sufficient time to permit step 1 registration within 180 days of the initial resection. These same conditions apply in the setting of a second surgical procedure, although if a second surgery is completed, step 1 registration must still occur with 180 days of initial surgery. Computed tomography (CT) imaging is not required, but may be obtained if desired clinically, for instance to assess calcifications or hyperostosis

The patient or a legally authorized representative must provide study-specific informed consent prior to study entry

NOTE: Central pathology review must occur between steps 1 and 2 of registration. Once appropriate pathology specimens are received, central pathology review will occur within 10 business days, and must confirm WHO grade II meningioma before the patient can proceed to step 2 registration and randomization

PRIOR TO STEP 2 REGISTRATION:

Histologically confirmed diagnosis of WHO grade II meningioma confirmed by central pathology review prior to step 2 registration

Age >= 18

History/physical examination, including neurologic examination within 60 days prior to step 2 registration

Post-operative Zubrod performance status 0-1 within 60 days prior to step 2 registration

If the patient is a woman is of childbearing potential, a serum pregnancy test, obtained within 14 days prior to step 2 registration, must be negative, and, if randomized to receive radiation therapy, the woman must agree to use contraception

Exclusion Criteria:

Optic nerve sheath meningioma, spinal or other extracranial meningioma, multiple meningiomas, hemangiopericytoma

Definitive evidence of metastatic meningioma (metastasis, although rare, can occur and is exclusionary)

Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years (carcinoma in situ of the breast, oral cavity, cervix, melanoma in situ, or other non-invasive malignancies are permissible)

Previous radiotherapy to the scalp, cranium, brain, or skull base and radiation-induced meningiomas

Major medical illnesses or psychiatric impairments, which in the investigators opinion, will prevent administration or completion of the protocol therapy and/or preclude informed consent; these include, but are not restricted to:

Unstable angina and/or congestive heart failure requiring hospitalization at the time of step 2 registration

Transmural myocardial infarction within the last 6 months prior to step 2 registration

Acute bacterial or fungal infection requiring intravenous antibiotics at the time of step 2 registration

Chronic obstructive pulmonary disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of step 2 registration

Type II neurofibromatosis (NF2)

Ailments entailing substantial increases in sensitivity and side effect risk from radiation therapy (ataxia telangiectasia, Nijmegen breakage syndrome, and human immunodeficiency virus (HIV) with CD4 count < 200 cells/microliter); HIV testing is not required for eligibility for this protocol, and known HIV positive patients are eligible, provided they are under treatment with highly active antiretroviral therapy (HAART) and have a CD4 count >= 200 cells/microliter within 30 days prior to step 2 registration

Inability to undergo MRI with and without contrast (e.g. claustrophobia, non-MRI compatible implant or foreign body, gadolinium allergy or renal dysfunction preventing the patient from receiving gadolinium- institutional guidelines should be used to determine if patients are at risk for renal dysfunction). Note that patients with severe claustrophobia are permitted on this study if they are willing and able to undergo MRI with adequate sedation or anesthesia

University of Alabama at Birmingham Cancer CenterActive, not recruiting

Birmingham, Alabama 35233, United States

Saint Joseph's Hospital and Medical CenterSuspended

Phoenix, Arizona 85013, United States

Mayo Clinic Hospital in ArizonaActive, not recruiting

Phoenix, Arizona 85054, United States

Mayo Clinic in ArizonaActive, not recruiting

Scottsdale, Arizona 85259, United States

University of Arizona Cancer Center-Orange Grove CampusSuspended

Tucson, Arizona 85704, United States

Banner University Medical Center - TucsonSuspended

Tucson, Arizona 85719, United States

University of Arizona Cancer Center-North CampusSuspended

Tucson, Arizona 85719, United States

Kaiser Permanente-AnaheimRecruiting

Anaheim, California 92806, United States

Sutter Cancer Centers Radiation Oncology Services-AuburnRecruiting

Auburn, California 95603, United States

Kaiser Permanente-BellflowerRecruiting

Bellflower, California 90706, United States

Kaiser Permanente DublinRecruiting

Dublin, California 94568, United States

Kaiser Permanente Los Angeles Medical CenterRecruiting

Los Angeles, California 90027, United States

Los Angeles General Medical CenterActive, not recruiting

Los Angeles, California 90033, United States

USC / Norris Comprehensive Cancer CenterActive, not recruiting

Los Angeles, California 90033, United States

Memorial Medical CenterRecruiting

Modesto, California 95355, United States

Kaiser Permanente Oakland-BroadwayRecruiting

Oakland, California 94611, United States

Kaiser Permanente-OntarioRecruiting

Ontario, California 91761, United States

UC Irvine Health/Chao Family Comprehensive Cancer CenterRecruiting

Orange, California 92868, United States

Stanford Cancer Institute Palo AltoActive, not recruiting

Palo Alto, California 94304, United States

Kaiser Permanente-Rancho Cordova Cancer CenterRecruiting

Rancho Cordova, California 95670, United States

Rohnert Park Cancer CenterRecruiting

Rohnert Park, California 94928, United States

Sutter Cancer Centers Radiation Oncology Services-RosevilleRecruiting

Roseville, California 95661, United States

The Permanente Medical Group-Roseville Radiation OncologyRecruiting

Roseville, California 95678, United States

Sutter Medical Center SacramentoRecruiting

Sacramento, California 95816, United States

South Sacramento Cancer CenterRecruiting

Sacramento, California 95823, United States

California Pacific Medical Center-Pacific CampusRecruiting

San Francisco, California 94115, United States

Kaiser Permanente Medical Center - Santa ClaraRecruiting

Santa Clara, California 95051, United States

Kaiser Permanente Cancer Treatment CenterRecruiting

South San Francisco, California 94080, United States

Sutter Solano Medical Center/Cancer CenterRecruiting

Vallejo, California 94589, United States

Hartford HospitalRecruiting

Hartford, Connecticut 06102, United States

Yale UniversityActive, not recruiting

New Haven, Connecticut 06520, United States

Smilow Cancer Hospital Care Center-TrumbullRecruiting

Trumbull, Connecticut 06611, United States

Helen F Graham Cancer CenterActive, not recruiting

Newark, Delaware 19713, United States

Christiana Care Health System-Christiana HospitalActive, not recruiting

Newark, Delaware 19718, United States

Beebe Health CampusActive, not recruiting

Rehoboth Beach, Delaware 19971, United States

TidalHealth Nanticoke / Allen Cancer CenterActive, not recruiting

Seaford, Delaware 19973, United States

Boca Raton Regional HospitalActive, not recruiting

Boca Raton, Florida 33486, United States

UM Sylvester Comprehensive Cancer Center at Coral GablesRecruiting

Coral Gables, Florida 33146, United States

UM Sylvester Comprehensive Cancer Center at Deerfield BeachRecruiting

Deerfield Beach, Florida 33442, United States

UM Sylvester Comprehensive Cancer Center at DoralRecruiting

Doral, Florida 33166, United States

Memorial Regional Hospital/Joe DiMaggio Children's HospitalRecruiting

Hollywood, Florida 33021, United States

Baptist MD Anderson Cancer CenterActive, not recruiting

Jacksonville, Florida 32207, United States

University of Miami Miller School of Medicine-Sylvester Cancer CenterRecruiting

Miami, Florida 33136, United States

Miami Cancer InstituteActive, not recruiting

Miami, Florida 33176, United States

AdventHealth OrlandoSuspended

Orlando, Florida 32803, United States

AdventHealth East OrlandoSuspended

Orlando, Florida 32822, United States

Memorial Hospital WestRecruiting

Pembroke Pines, Florida 33028, United States

UM Sylvester Comprehensive Cancer Center at PlantationRecruiting

Plantation, Florida 33324, United States

Moffitt Cancer CenterSuspended

Tampa, Florida 33612, United States

Grady Health SystemRecruiting

Atlanta, Georgia 30303, United States

Emory Proton Therapy CenterRecruiting

Atlanta, Georgia 30308, United States

Piedmont HospitalRecruiting

Atlanta, Georgia 30309, United States

Emory University Hospital/Winship Cancer InstituteRecruiting

Atlanta, Georgia 30322, United States

Emory Saint Joseph's HospitalRecruiting

Atlanta, Georgia 30342, United States

Northside HospitalActive, not recruiting

Atlanta, Georgia 30342, United States

Northside Hospital-ForsythActive, not recruiting

Cumming, Georgia 30041, United States

Piedmont Fayette HospitalRecruiting

Fayetteville, Georgia 30214, United States

Piedmont Newnan HospitalRecruiting

Newnan, Georgia 30265, United States

Piedmont Henry HospitalRecruiting

Stockbridge, Georgia 30281, United States

Queen's Medical CenterRecruiting

Honolulu, Hawaii 96813, United States

The Cancer Center of Hawaii-LilihaSuspended

Honolulu, Hawaii 96817, United States

Northwestern UniversityRecruiting

Chicago, Illinois 60611, United States

Rush MD Anderson Cancer CenterRecruiting

Chicago, Illinois 60612, United States

University of IllinoisRecruiting

Chicago, Illinois 60612, United States

Decatur Memorial HospitalActive, not recruiting

Decatur, Illinois 62526, United States

NorthShore University HealthSystem-Evanston HospitalRecruiting

Evanston, Illinois 60201, United States

Northwestern Medicine Cancer Center DelnorRecruiting

Geneva, Illinois 60134, United States

NorthShore University HealthSystem-Glenbrook HospitalRecruiting

Glenview, Illinois 60026, United States

NorthShore University HealthSystem-Highland Park HospitalRecruiting

Highland Park, Illinois 60035, United States

Loyola University Medical CenterRecruiting

Maywood, Illinois 60153, United States

Northwestern Medicine Cancer Center WarrenvilleRecruiting

Warrenville, Illinois 60555, United States

Indiana University/Melvin and Bren Simon Cancer CenterActive, not recruiting

Indianapolis, Indiana 46202, United States

IU Health Methodist HospitalActive, not recruiting

Indianapolis, Indiana 46202, United States

Iowa Methodist Medical CenterRecruiting

Des Moines, Iowa 50309, United States

University of Iowa/Holden Comprehensive Cancer CenterActive, not recruiting

Iowa City, Iowa 52242, United States

University of Kansas Cancer CenterActive, not recruiting

Kansas City, Kansas 66160, United States

University of Kansas Cancer Center-Overland ParkActive, not recruiting

Overland Park, Kansas 66210, United States

University of Kentucky/Markey Cancer CenterActive, not recruiting

Lexington, Kentucky 40536, United States

The James Graham Brown Cancer Center at University of LouisvilleRecruiting

Louisville, Kentucky 40202, United States

UofL Health Medical Center NortheastRecruiting

Louisville, Kentucky 40245, United States

LSU Health Sciences Center at ShreveportActive, not recruiting

Shreveport, Louisiana 71103, United States

MaineHealth Coastal Cancer Treatment CenterRecruiting

Bath, Maine 04530, United States

MaineHealth Maine Medical Center - PortlandRecruiting

Portland, Maine 04102, United States

MaineHealth Cancer Care Center of York CountyRecruiting

Sanford, Maine 04073, United States

MaineHealth Maine Medical Center- ScarboroughRecruiting

Scarborough, Maine 04074, United States

Maryland Proton Treatment CenterActive, not recruiting

Baltimore, Maryland 21201, United States

University of Maryland/Greenebaum Cancer CenterActive, not recruiting

Baltimore, Maryland 21201, United States

Tufts Medical CenterRecruiting

Boston, Massachusetts 02111, United States

Trinity Health Saint Joseph Mercy Hospital Ann ArborSuspended

Ann Arbor, Michigan 48106, United States

University of Michigan Rogel Cancer CenterActive, not recruiting

Ann Arbor, Michigan 48109, United States

Chelsea HospitalSuspended

Chelsea, Michigan 48118, United States

Henry Ford Macomb Hospital-Clinton TownshipRecruiting

Clinton Township, Michigan 48038, United States

Henry Ford HospitalRecruiting

Detroit, Michigan 48202, United States

Henry Ford Health Saint John HospitalSuspended

Detroit, Michigan 48236, United States

Trinity Health Grand Rapids HospitalRecruiting

Grand Rapids, Michigan 49503, United States

Trinity Health Saint Mary Mercy Livonia HospitalSuspended

Livonia, Michigan 48154, United States

MyMichigan Medical Center SaginawSuspended

Saginaw, Michigan 48601, United States

Henry Ford Health Warren HospitalSuspended

Warren, Michigan 48093, United States

Henry Ford West Bloomfield HospitalRecruiting

West Bloomfield, Michigan 48322, United States

University of Michigan Health - WestRecruiting

Wyoming, Michigan 49519, United States

Essentia Health Cancer CenterRecruiting

Duluth, Minnesota 55805, United States

Miller-Dwan HospitalRecruiting

Duluth, Minnesota 55805, United States

Abbott-Northwestern HospitalRecruiting

Minneapolis, Minnesota 55407, United States

Mayo Clinic in RochesterRecruiting

Rochester, Minnesota 55905, United States

Park Nicollet Clinic - Saint Louis ParkRecruiting

Saint Louis Park, Minnesota 55416, United States

Regions HospitalRecruiting

Saint Paul, Minnesota 55101, United States

University of Mississippi Medical CenterActive, not recruiting

Jackson, Mississippi 39216, United States

Siteman Cancer Center at Saint Peters HospitalRecruiting

City of Saint Peters, Missouri 63376, United States

MU Health - University Hospital/Ellis Fischel Cancer CenterActive, not recruiting

Columbia, Missouri 65212, United States

Siteman Cancer Center at West County HospitalRecruiting

Creve Coeur, Missouri 63141, United States

Washington University School of MedicineRecruiting

St Louis, Missouri 63110, United States

Siteman Cancer Center-South CountyRecruiting

St Louis, Missouri 63129, United States

Billings Clinic Cancer CenterSuspended

Billings, Montana 59101, United States

Benefis Sletten Cancer InstituteRecruiting

Great Falls, Montana 59405, United States

Logan Health Medical CenterSuspended

Kalispell, Montana 59901, United States

University of Nebraska Medical CenterActive, not recruiting

Omaha, Nebraska 68198, United States

Dartmouth Hitchcock Medical Center/Dartmouth Cancer CenterRecruiting

Lebanon, New Hampshire 03756, United States

Memorial Sloan Kettering Basking RidgeActive, not recruiting

Basking Ridge, New Jersey 07920, United States

Englewood Hospital and Medical CenterRecruiting

Englewood, New Jersey 07631, United States

Memorial Sloan Kettering MonmouthActive, not recruiting

Middletown, New Jersey 07748, United States

Memorial Sloan Kettering BergenActive, not recruiting

Montvale, New Jersey 07645, United States

Jersey Shore Medical CenterRecruiting

Neptune City, New Jersey 07753, United States

Rutgers Cancer Institute of New JerseyRecruiting

New Brunswick, New Jersey 08903, United States

Rutgers New Jersey Medical SchoolSuspended

Newark, New Jersey 07101, United States

Capital Health Medical Center-HopewellRecruiting

Pennington, New Jersey 08534, United States

ProCure Proton Therapy Center-SomersetActive, not recruiting

Somerset, New Jersey 08873, United States

Robert Wood Johnson University Hospital SomersetActive, not recruiting

Somerville, New Jersey 08876, United States

University of New Mexico Cancer CenterRecruiting

Albuquerque, New Mexico 87106, United States

New York-Presbyterian/Brooklyn Methodist HospitalRecruiting

Brooklyn, New York 11215, United States

Memorial Sloan Kettering CommackActive, not recruiting

Commack, New York 11725, United States

The New York Hospital Medical Center of QueensActive, not recruiting

Flushing, New York 11355, United States

Memorial Sloan Kettering WestchesterActive, not recruiting

Harrison, New York 10604, United States

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterActive, not recruiting

New York, New York 10032, United States

Memorial Sloan Kettering Cancer CenterActive, not recruiting

New York, New York 10065, United States

NYP/Weill Cornell Medical CenterSuspended

New York, New York 10065, United States

University of RochesterActive, not recruiting

Rochester, New York 14642, United States

Memorial Sloan Kettering NassauActive, not recruiting

Uniondale, New York 11553, United States

Westchester Medical CenterSuspended

Valhalla, New York 10595, United States

UNC Lineberger Comprehensive Cancer CenterActive, not recruiting

Chapel Hill, North Carolina 27599, United States

Case Western Reserve UniversityRecruiting

Cleveland, Ohio 44106, United States

Cleveland Clinic FoundationRecruiting

Cleveland, Ohio 44195, United States

Ohio State University Comprehensive Cancer CenterRecruiting

Columbus, Ohio 43210, United States

Mercy Cancer Center-ElyriaSuspended

Elyria, Ohio 44035, United States

Kettering Medical CenterActive, not recruiting

Kettering, Ohio 45429, United States

UH Seidman Cancer Center at Lake Health Mentor CampusRecruiting

Mentor, Ohio 44060, United States

ProMedica Flower HospitalRecruiting

Sylvania, Ohio 43560, United States

UHHS-Westlake Medical CenterActive, not recruiting

Westlake, Ohio 44145, United States

University of Oklahoma Health Sciences CenterSuspended

Oklahoma City, Oklahoma 73104, United States

Legacy Mount Hood Medical CenterActive, not recruiting

Gresham, Oregon 97030, United States

Legacy Good Samaritan Hospital and Medical CenterActive, not recruiting

Portland, Oregon 97210, United States

Saint Luke's University Hospital-Bethlehem CampusActive, not recruiting

Bethlehem, Pennsylvania 18015, United States

Christiana Care Health System-Concord Health CenterActive, not recruiting

Chadds Ford, Pennsylvania 19317, United States

Geisinger Medical CenterRecruiting

Danville, Pennsylvania 17822, United States

Geisinger Medical Oncology-LewisburgRecruiting

Lewisburg, Pennsylvania 17837, United States

Lewistown HospitalRecruiting

Lewistown, Pennsylvania 17044, United States

Thomas Jefferson University HospitalActive, not recruiting

Philadelphia, Pennsylvania 19107, United States

Fox Chase Cancer CenterActive, not recruiting

Philadelphia, Pennsylvania 19111, United States

Temple University HospitalSuspended

Philadelphia, Pennsylvania 19140, United States

Geisinger Cancer Services-PottsvilleRecruiting

Pottsville, Pennsylvania 17901, United States

Geisinger Wyoming Valley/Henry Cancer CenterRecruiting

Wilkes-Barre, Pennsylvania 18711, United States

Lankenau Medical CenterSuspended

Wynnewood, Pennsylvania 19096, United States

Prisma Health Cancer Institute - SpartanburgActive, not recruiting

Boiling Springs, South Carolina 29316, United States

Medical University of South CarolinaActive, not recruiting

Charleston, South Carolina 29425, United States

Prisma Health Cancer Institute - FarisActive, not recruiting

Greenville, South Carolina 29605, United States

Prisma Health Cancer Institute - EastsideActive, not recruiting

Greenville, South Carolina 29615, United States

Prisma Health Cancer Institute - GreerActive, not recruiting

Greer, South Carolina 29650, United States

Prisma Health Cancer Institute - SenecaActive, not recruiting

Seneca, South Carolina 29672, United States

Vanderbilt University/Ingram Cancer CenterActive, not recruiting

Nashville, Tennessee 37232, United States

UT Southwestern/Simmons Cancer Center-DallasRecruiting

Dallas, Texas 75390, United States

UT MD Anderson Cancer CenterActive, not recruiting

Houston, Texas 77030, United States

University of Texas Health Science Center at San AntonioActive, not recruiting

San Antonio, Texas 78229, United States

American Fork Hospital / Huntsman Intermountain Cancer CenterRecruiting

American Fork, Utah 84003, United States

Logan Regional HospitalRecruiting

Logan, Utah 84321, United States

Intermountain Medical CenterRecruiting

Murray, Utah 84107, United States

McKay-Dee Hospital CenterRecruiting

Ogden, Utah 84403, United States

Utah Valley Regional Medical CenterRecruiting

Provo, Utah 84604, United States

Riverton HospitalRecruiting

Riverton, Utah 84065, United States

LDS HospitalRecruiting

Salt Lake City, Utah 84143, United States

Dartmouth Cancer Center - NorthRecruiting

Saint Johnsbury, Vermont 05819, United States

VCU Massey Comprehensive Cancer CenterActive, not recruiting

Richmond, Virginia 23298, United States

University of Washington Medical Center - MontlakeActive, not recruiting

Seattle, Washington 98195, United States

Legacy Salmon Creek HospitalActive, not recruiting

Vancouver, Washington 98686, United States

Langlade Hospital and Cancer CenterRecruiting

Antigo, Wisconsin 54409, United States

Marshfield Medical Center-EC Cancer CenterRecruiting

Eau Claire, Wisconsin 54701, United States

University of Wisconsin Carbone Cancer Center - Eastpark Medical CenterRecruiting

Madison, Wisconsin 53718, United States

University of Wisconsin Carbone Cancer Center - University HospitalRecruiting

Madison, Wisconsin 53792, United States

Marshfield Medical Center-MarshfieldRecruiting

Marshfield, Wisconsin 54449, United States

Froedtert Menomonee Falls HospitalRecruiting

Menomonee Falls, Wisconsin 53051, United States

Medical College of WisconsinRecruiting

Milwaukee, Wisconsin 53226, United States

Marshfield Medical Center - MinocquaRecruiting

Minocqua, Wisconsin 54548, United States

Drexel Town Square Health CenterRecruiting

Oak Creek, Wisconsin 53154, United States

Marshfield Medical Center-Rice LakeRecruiting

Rice Lake, Wisconsin 54868, United States

Aspirus Cancer Care - Stevens PointRecruiting

Stevens Point, Wisconsin 54481, United States

Marshfield Medical Center-River Region at Stevens PointRecruiting

Stevens Point, Wisconsin 54482, United States

UW Cancer Center at ProHealth CareRecruiting

Waukesha, Wisconsin 53188, United States

Aspirus Regional Cancer CenterRecruiting

Wausau, Wisconsin 54401, United States

Marshfield Medical Center - WestonRecruiting

Weston, Wisconsin 54476, United States

Aspirus Cancer Care - Wisconsin RapidsRecruiting

Wisconsin Rapids, Wisconsin 54494, United States

Arthur J E Child Comprehensive Cancer CentreSuspended

Calgary, Alberta T2N 5G2, Canada

Cross Cancer InstituteActive, not recruiting

Edmonton, Alberta T6G 1Z2, Canada

Juravinski Cancer Centre at Hamilton Health SciencesRecruiting

Hamilton, Ontario L8V 5C2, Canada

London Regional Cancer ProgramSuspended

London, Ontario N6A 4L6, Canada

University Health Network-Princess Margaret HospitalRecruiting

Toronto, Ontario M5G 2M9, Canada

CHUM - Centre Hospitalier de l'Universite de MontrealSuspended

Montreal, Quebec H2X 3E4, Canada

The Research Institute of the McGill University Health Centre (MUHC)Suspended

Montreal, Quebec H3H 2R9, Canada

Allan Blair Cancer CentreActive, not recruiting

Regina, Saskatchewan S4T 7T1, Canada

Tata Memorial HospitalSuspended

Mumbai, 400 012, India

Hokkaido University HospitalRecruiting

Sapporo, Hokkaido 060-8648, Japan

Iwate Medical University HospitalSuspended

Shiwa-gun, Iwate 028-3695, Japan

Kyorin University HospitalRecruiting

Mitaka-shi, Tokyo 181-8611, Japan

Site Public ContactContact

Roster@nrgoncology.org412-339-5294

Keio UniversityRecruiting

Shinjuku-ku, Tokyo 160-8582, Japan

Site Public ContactContact

03 5363-3848

Hiroshima University HospitalRecruiting

Hiroshima, 734-8551, Japan

Saitama Medical University International Medical CenterRecruiting

Saitama, 350-1298, Japan

National Cancer Center HospitalRecruiting

Tokyo, 104 0045, Japan

King Faisal Specialist Hospital and Research CentreSuspended

Riyadh, 11211, Saudi Arabia