Combined HCC-MFCCC

Survival After Hepatectomy for Combined Hepatocellular Cholagiocarcinoma

Combined hepatocellular and mass-forming cholangiocarcinoma (cHCC-MFCCC) is a rare tumor. The aim of this study was the analysis of the outcome comparing such tumor with classic hepatocellular carcinoma (HCC) and mass-forming cholangiocarcinoma (MFCCC).

The institutional prospectively maintained database was queried, and 20 patients with cHCC-MFCCC were identified. A 2:1 match was performed with 40 patients operated in the same period for HCC, and with 40 operated for MFCCC. Only T1 or T2 patients N0 M0 were considered. Primary endpoint was the overall survival (OS) and disease-free survival (DFS).

Inclusion Criteria:

• positive histology for cHCC-MFCCC, HCC, and MFCCC
• complete clinical, surgical, pathological and follow-up data.

Exclusion Criteria:

• patients preoperatively treated with chemotherapy, radiofrequency ablation or trans-arterial therapies were excluded.
• patients operated for recurrent disease and/or with non-radical surgery
• patients with missing data were also excluded