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This study will pilot a strengthening intervention targeted to muscles found to be important to gait in people with multiple sclerosis (MS). Previous studies that have tried to strengthen leg and trunk muscles in people with MS have failed to improve walking ability consistently. The investigators think that is because strengthening exercises were not targeted to the correct muscle groups. For this study the investigators propose targeting muscle groups that they have found to be strong contributors to walking in a prior study. This is the first study to target these muscles, so the investigators propose doing a small trial to first evaluate the feasibility of the strength program and the outcomes. The investigators will measure strength and walking measures twice before and once after an 8-week strengthening intervention in a single group of 10 people with MS who are able to walk independently. The results of this study will help inform future, larger trials that could change the way strength training is conducted in people with MS.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Strength training | Experimental | Strength exercises for ankle PF, hip abduction, and trunk muscles. Exercises will be done in three standard positions of supine, sidelying, prone, seated, and standing. Exercises during the initial 4 weeks will be completed 2x week with supervision of a physical therapist and 2x week at home, for a total of 4x week. For the final 4 weeks of the intervention will be completed 1x week with supervision and 3x week at home. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Strength exercise | Other | Strengthening exercises performed with physical therapist. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Muscle Strength | Muscle strength measured by hand-held dynamometry (HHD) and clinical strength tests | Week 0 (Baseline 1); Week 1 (Baseline 2); Week 10 (Follow-Up) |
| Change in Timed 25 Foot Walk (T25FW) | Gait speed over a 25 foot distance | Week 0 (Baseline 1); Week 1 (Baseline 2); Week 10 (Follow-Up) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in 6-Minute Walk Test | Gait endurance | Week 0 (Baseline 1); Week 1 (Baseline 2); Week 10 (Follow-Up) |
| Change in Dynamic Gait Index | Balance during gait and other functional activities |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Margaret Schenkman, PT, PhD | University of Colorado, Denver | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Denver | Aurora | Colorado | 80045 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29070966 | Background | Manago MM, Hebert JR, Schenkman M. Psychometric Properties of a Clinical Strength Assessment Protocol in People with Multiple Sclerosis. Int J MS Care. 2017 Sep-Oct;19(5):253-262. doi: 10.7224/1537-2073.2016-078. |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| Week 0 (Baseline 1); Week 1 (Baseline 2); Week 10 (Follow-Up) |
| Change in Multiple Sclerosis Walking Scale-12 | Self-report measure of limitations in walking related activities | Week 0 (Baseline 1); Week 1 (Baseline 2); Week 10 (Follow-Up) |
| Change in Patient Specific Functional Scale | Self reported measure of self-selected limitations in participation | Week 0 (Baseline 1); Week 10 (Follow-Up) |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |