Exploratory Study of TAC-302 in Detrusor Underactivity Patients With Overactive Bladder.

Exploratory Study of TAC-302 in Detrusor Underactivity Patients With Overactive Bladder.

The purpose of this study is to evaluate the efficacy and safety of TAC-302 in detrusor underactivity patients with overactive bladder.

The main purpose of this study is to assess the efficacy of TAC-302 for 12 weeks in detrusor underactivity patients with overactive bladder by measuring the following parameters of pressure-flow study.

• Male; bladder contractility index (BCI)
• Female; projected isovolumetric pressure (PIP) 1

Key Inclusion Criteria:

• To have Lower Urinary Tract Symptoms for at least 12 weeks prior to study entry
• To have at least 1 urinary urgency episodes per day, and diurnal urinary frequency of 8 or more per day.
• To meet the detrusor underactivity criteria by urodynamic study

Key Exclusion Criteria:

• Neurogenic bladder by the central nervous system diseases.
• StageIII or more cystocele of pelvic organ prolapse quantification system (women)
• Prostate volume ≥30mL (Men)
• Any symptoms of Urinary tract infection (UTI)