Non-alcoholic fatty liver disease is the most common cause of chronic liver disease worldwide. It is defined as the accumulation of fat (>5%) in the liver cells in the absence of excessive alcohol intake or other causes of liver disease including viral, drug-induced, or autoimmune. Non-alcoholic fatty liver disease is a hepatic manifestation of metabolic syndrome.

Inclusion criteria:

• All non alcoholic fatty liver disease patients evidenced by abdominal ultrasound.
• Urine analysis whether normal or renal sedimentation.

Exclusion criteria:

1. Alcoholic fatty liver patients.
2. patients known to have diabetes mellitus.
3. patients with other causes of liver disease as viral hepatitis, drug induced,or autoimmune.
4. patients known to have kidney disease.
5. Hypertension.
6. Hyperuricemia.
7. Impaired urea and creatinine patients.

Patients will be recruited outpatient clinic of internal medicine of Luxor international hospital and Assiut university hospital