Skeletal Muscle Expression of Myostatin and Cancer of Digestive System Associated Cachexia

Skeletal Muscle Expression of Myostatin and Cancer of Digestive System Associated Cachexia(MYOCAC Study)

Cancer cachexia is responsible for the death of approximately 20% of patients. Myostatin is a master negative regulator of skeletal muscle mass. If the role of myostatin in cancer cachexia is now well established in murine models, no study has focused on muscle expression of Myostatin in relation to the degree of cachexia. the hypothesize is that muscle Myostatin a biological marker of cachexia in patients with cancer of digestive system. The main objective is to compare skeletal muscle Myostatin messenger RiboNucleic Acid (mRNA) level as a function of cachexia in cancer of digestive system patients. Myostatin messenger RiboNucleic Acid (mRNA) level will be determined in a muscle sample taken during the resection under general anaesthesia. Skeletal muscle index will be determined before surgery, 3 and 6 months after surgery. Muscle strength of the lower and upper limbs will be determined before resection, at 1 month, 3 months and 6 months postoperatively. Blood sampling will also be performed on these 4 occasions.

Inclusion Criteria:

• Women and men aged 40-80.
• Diagnosis for cancer of digestive system requiring surgery with neoadjuvant treatment or not.
• Signature of consent
• Affiliate or beneficiary of social security

Exclusion Criteria:

• Administration of corticosteroids.
• Thyroid disease treated.
• Severe chronic pathology during treatment (neuro-muscular pathologies, renal insufficiency requiring dialysis, COPD under continuous oxygen therapy).
• Psychological, familial, social or geographical conditions that could affect the participation of the subject throughout the duration of the protocol.
• BMI> 30 due to the difficulty of interpretation of BMI variations in obese patients