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| Name | Class |
|---|---|
| Singapore University of Technology and Design | UNKNOWN |
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To develop and validate a library of cough spectrum from a target of 1000 cough acoustics. Coughs arising from upper respiratory infection, lower chest infections, asthma, allergic conditions are included in the study. Cough acoustic in absence of respiratory disease is also included.
This is a prospective observation cohort study recruiting children below the age of 16 years old in 2 arms : (1) Patients with respiratory conditions presenting with cough and (2) Well patients without active coughing.
Cough is a common presentation in childhood. It is one of the early symptom of respiratory disease such as upper respiratory tract infection, cough variant asthma, allergic rhinitis, bronchitis and pneumonia. These conditions are common ailments in childhood. The history of cough and description of cough given by caretakers and patients are often vague and assessment of cough quality is often subjective. The quality of cough is often assigned a dichotomous category of dry cough and wet cough.
Computer assisted cough analysis has been developed in recent years to aid subjective classification of cough. The sound spectrum and frequencies of cough is being researched to better define the quality of cough. The quality of cough gives meaningful information about the state of the respiratory status. Cough sound analysis has been shown to rapidly diagnose pneumonia in humans using cough sound analysis and in differentiating wet and dry cough.
The investigators hypothesize that each respiratory pathology will have its spectral cough characteristics. Analysis of cough spectrum and comparing to a library of cough spectra data will be able to aid differentiation of the underlying conditions for the various cough spectrum and hence facilitating management.
The study aim is to develop a computer processing technique of cough sounds and determine their spectral characteristics for the common causes of cough to derive an assisted assay of cough spectrum for an objective assessment of cough.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cough Arm | Children age 16 years old and below with cough at presentation - Patients presenting with active or chronic or residual cough | ||
| Well Arm | Children age 16 years old and below and Well with no presentation of cough |
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| Measure | Description | Time Frame |
|---|---|---|
| Acute phase acoustic spectrum Analysis | Acoustic classifiers | Day 0-7 |
| Measure | Description | Time Frame |
|---|---|---|
| Recovery or Chronic phase acoustic spectrum analysis | Acoustic classifiers | Day 7-30 |
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Inclusion Criteria:
Well arm
1.Children age 16 years old and below and Well with no cough presentation.
Exclusion Criteria:
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This is a prospective observation cohort study will recruit children below the age of 16 years old.
There will be 2 arms : (1) Patients with respiratory conditions presenting with cough and (2) well patient without cough.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hwan Ing Hee, MBBCH BAO | Contact | 65-81252657 | hee.hwan.ing@singhealth.com.sg | |
| Nur Diyanah Siti | Contact | 65-63948459 | 8459 | Siti.Nur.Diyanah@kkh.com.sg |
| Name | Affiliation | Role |
|---|---|---|
| Hwan Ing Hee, MBBCH BAO | KK Women's and Children's Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| KKWCH | Recruiting | Singapore | 229899 | Singapore |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33003873 | Derived | B T B, Hee HI, Teoh OH, Lee KP, Kapoor S, Herremans D, Chen JM. Asthmatic versus healthy child classification based on cough and vocalised /a:/ sounds. J Acoust Soc Am. 2020 Sep;148(3):EL253. doi: 10.1121/10.0001933. |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 28, 2019 | |
| Reset | Dec 19, 2019 | |
| Release | Feb 21, 2020 | |
| Reset | Mar 5, 2020 | |
| Release | Sep 16, 2020 | |
| Reset | Oct 8, 2020 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 28, 2019 | Dec 19, 2019 | |||
| Feb 21, 2020 |
| ID | Term |
|---|---|
| D003371 | Cough |
| D000096823 | Cough-Variant Asthma |
| D007251 | Influenza, Human |
| ID | Term |
|---|---|
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
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| Mar 5, 2020 |
| Sep 16, 2020 | Oct 8, 2020 |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001249 | Asthma |
| D001982 | Bronchial Diseases |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012130 | Respiratory Hypersensitivity |
| D006969 | Hypersensitivity, Immediate |
| D006967 | Hypersensitivity |
| D007154 | Immune System Diseases |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D009976 | Orthomyxoviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |