The Effect of Direct Antiviral Therapy on Hepatitis c Virus-related Thrombocytopenia

The Effect of Direct Antiviral Therapy on Hepatitis c Virus-related Thrombocytopenia

Autoimmune thrombocytopenic purpura is an immunological disorder characterized by increased platelet destruction due to presence of anti-platelet antibodies. Hepatitis C virus infection, which is one of the most common chronic viral infections worldwide, may cause secondary chronic immune thrombocytopenic purpura. It seemed to play a pathogenic role in autoimmune thrombocytopenic purpura. Moreover, the successful response (negative hepatitis C virus - ribonucleic acid) to tapered steroids and antiviral therapy was useful to revert thrombocytopenia

Inclusion Criteria:

• Hepatitis C virus infection and thrombocytopenia before treatment

Exclusion Criteria:

• Infection Hepatitis B virus
• Hypersplenism
• Diseases affecting Bone marrow
• Major clotting factors abnormalities eg. Disseminated intravascular coagulopathy, severe Prothrombin deficiency