Performance in Walking in Osteoarthritis Patients | NCT03167502

Studies
Performance in Walking in Osteoarthritis Patients

NCT03167502

Sponsor

Centre Hospitalier Universitaire de Nice

Status

Completed

Last Update Posted

Mar 24, 2026Actual

Enrollment

40Actual

Phase

Not Applicable

Conditions

Osteoarthritis

Interventions

eccentric work
concentric work

Countries

France

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Mar 2026

Overall Recruitment Status or Expanded Access Status

Completed

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Sep 19, 2017Actual

Primary Completion Date

Nov 25, 2017Actual

Completion Date

Jun 17, 2019Actual

First Submitted Date

May 24, 2017

First Submission Date that Met QC Criteria

May 24, 2017

First Posted Date

May 30, 2017Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Mar 20, 2026

Last Update Posted Date

Mar 24, 2026Actual

Oversight Module

Has Data Monitoring Committee (DMC)

Is FDA Regulated Drug

Is FDA Regulated Device

Is Unapproved Device

Not provided

Pediatric Postmarket Surveillance of a Device Product

Not provided

Product Exported from US

Not provided

FDAAA801 Violation

Not provided

Description Module

Brief Summary

Detailed Description

Few data exist to date on the effect of eccentric muscle building in knee osteoarthritis. No studies have compared the effect of eccentric versus concentric reinforcement in knee osteoarthritis. Our study aims to show the effectiveness of an eccentric reinforcement, the interest of a work supervised by a sports coach to maintain activity over time and to study the effect of this activity at the muscular level. The main objective is to study the effect of an eccentric muscle strengthening program on walking performance in osteoarthritis patients. The secondary objectives are to study: the effect of fatigue on walking, the relationship between fatigue and the level of physical activity, the effect of training on perceived fatigue and the effect of training on the function and at muscular level. This is a randomized, interventional trial. 40 subjects are planned. Inclusion criteria include: age 40-85 years, KL 2 and 3. The subjects are divided into two groups to perform either eccentric or concentric work. 2 sessions per week for 6 weeks. At baseline and at the end of the study a clinical evaluation and MRI will be carried out for evaluation of the criteria of judgment

Design Module

Study Type

Interventional

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Not provided

Target Follow-Up Duration

Not provided

Phases

Not Applicable

Interventional Study Design

Allocation

Biospecimen

No data available

No data is available for this block.

Enrollment

40Actual

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
concentric work	Active Comparator	patient suffering from knee osteoarthritis will follow a concentric work. This training is 2 sessions per week for 6 weeks	Other: concentric work
eccentric work	Experimental	patient suffering from knee osteoarthritis will follow an eccentric work. This training is 2 sessions per week for 6 weeks	Other: eccentric work

Interventions

Name	Type	Description	Arm Group Labels	Other Names
eccentric work	Other	patient will follow 2 eccentric trainings per week during 6 weeks	eccentric work

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Walking performance	6-minute walk test	after 6 training weeks

Secondary Outcomes

Not provided

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Autonomous subjects aged 40 to 85
Subjects meeting ACR criteria for gonarthrosis
Subjects with a score of Kellgren and Lawrence at least one knee greater than or equal to 2
Signature of consent form
Subjects affiliated to social security

Exclusion Criteria:

Subject with a Kellgren and Lawrence stadium at 4 for at least one of his two knees

Subjects with symptomatic femoro-patellar arthrosis
Subject with a pathology that makes walking testing impossible.
Non-autonomous subjects, with a pathology impairing walking
Subjects with symptomatic osteoarthritis of the hip and / or with a hip or knee prosthesis
Subject incapable of signing consent and unable to understand information leaflet.

Accepts Healthy Volunteers

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

40 Years

Maximum Age

85 Years

Standard Ages

AdultOlder Adult

Study Population

Not provided

Sampling Method

Not provided

Contacts/Locations Module

Central Contacts

Not provided

Overall Officials

Name	Affiliation	Role
Christian H ROUX, PhD	service de Rhumatologie, CHU de NICE	Principal Investigator

Locations

Facility	Status	City	State	ZIP	Country	Contacts
Department of rheumatology, nice university hospital		Nice		06000	France

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
35832351	Result	Trojani MC, Chorin F, Gerus P, Breuil V, Michel C, Guis S, Bendahan D, Roux C. Concentric or eccentric physical activity for patients with symptomatic osteoarthritis of the knee: a randomized prospective study. Ther Adv Musculoskelet Dis. 2022 Jul 7;14:1759720X221102805. doi: 10.1177/1759720X221102805. eCollection 2022.

ID	Term
D001168	Arthritis
D007592	Joint Diseases
D009140	Musculoskeletal Diseases
D012216	Rheumatic Diseases