The purpose is to assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS TMPRSS6-Lrx Administered Subcutaneously for up to 44 Healthy Volunteers

Inclusion Criteria:

• Must have given written informed consent and be able to comply with all study requirements
• Healthy males or females aged 18-65 inclusive at the time of Informed Consent
• Females must be non-pregnant and non-lactating, and either surgically sterile or post- menopausal
• Males must be surgically sterile, abstinent or using an acceptable contraceptive method
• BMI < 32 kg/m2

Exclusion Criteria:

• Clinically significant abnormalities in medical history or physical examination
• Clinically significant lab abnormalities that would render a subject unsuitable for inclusion
• Known history or positive test for HIV, HCV, or HBV
• Treatment with another Study Drug, biological agent, or device within one-month of Screening or 5 half-lives of investigational agent, whichever is longer
• Smoking > 10 cigarettes per day
• Regular excessive use of alcohol within 6 months of screening
• Current use of concomitant medications other than occasional acetaminophen (paracetamol) or ibuprofen unless approved by Sponsor Medical Monitor
• Considered unsuitable for inclusion by the Investigator or Sponsor