GDFT Based on PPV Compared With Standard Fluid Therapy in Patients Undergoing Complex Spine Surgery: RCT

Goal Directed Fluid Therapy Based on Pulse Pressure Variation Compared With Standard Fluid Therapy in Patients Undergoing Complex Spine Surgery: a Randomized Controlled Trial

The investigators will do the Goal directed fluid therapy by protocolized fluid management in the experimental group, using PPV to guide the fluid administration, compare with standard fluid management in patients undergoing complex spine surgery.

Inclusion Criteria:

• ASA 1-3
• elective surgery
• thoracic/lumbar spine surgery >= 3 levels and duration >= 3 hours

Exclusion Criteria:

• Cr >2 mg/dl or eGFR < 60 ml/min
• coronary artery disease, congestive heart failure or cardiac arrhythmia
• BMI >30 kg/m2
• hemodynamic unstable, preoperatively
• uncontrolled hypertension
• respiratory system compliance < 30 ml/cmH2O