Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
All consecutive patients with liver cirrhosis, with clinical and imaging features suggestive of Hepatocellular Carcinoma (HCC) attending the Department of Hepatology, Institute of Liver and Biliary Sciences (ILBS) from February 2017 to December 2018 will be evaluated for inclusion.Based on the previous years data of HCC patients admitted to ILBS.
Cirrhotic patients aged 18-70 years, with HCC proven by typical radiological features of arterial enhancement and delayed wash-out, on one or both of dynamic Computerized Tomographic or dynamic Magnetic Resonance Imaging (MRI), as per updated American Association for the Study of Liver Disease (AASLD) guidelines (details in appendix1).
Age and gender matched patients with cirrhosis, but without HCC, seen during the same study period will serve as controls.
Patient characteristics, etiology of cirrhosis, and liver function parameters will be noted. Investigator will stage the included patients as per the Barcelona Cancer of Liver Cancer (BCLC) criteria (details in appendix1). Investigator will then estimate Circulating Tumor Cells (CTC) and cfDNA in peripheral blood samples of the patients and controls.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cirrhosis with HCC |
| ||
| Cirrhosis without HCC |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cirrhosis with HCC | Other | Cirrhosis with Hepatocellular Carcinoma |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Number of circulating tumor cells (CTCs) in cirrhotic patients with hepatocellular carcinoma (HCC) | Day 0 | |
| Number of cell-free DNA (cfDNA) in cirrhotic patients with hepatocellular carcinoma (HCC) | Day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Circulating Tumor Cells in the peripheral blood of cirrhotic patients in both groups | Day 0 | |
| To study the difference in amount of cfDNA in the peripheral blood of cirrhotic patients with and without HCC. | Difference would be found out by estimating cfDNA in terms of ng/mL of the blood specimen |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of Liver and Biliary Sciences | New Delhi | National Capital Territory of Delhi | 110070 | India |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Cirrhosis without HCC |
| Other |
Cirrhosis without Hepatocellular Carcinoma |
|
| Day 0 |
| Number of Circulatory Tumor Cells with the tumor size of HepatoCellular Carcinoma. | Day 0 |
| Number of Circulatory Tumor Cells with the tumor number of HepatoCellular Carcinoma. | Day 0 |
| Number of Circulatory Tumor Cells withBarcelona Clinic of Liver Cancer (BCLC) stage of HepatoCellular Carcinoma. | Day 0 |
| Number of cfDNA amount with the tumor size of HepatoCellular Carcinoma. | Day 0 |
| Number of cfDNA amount with the tumor number of HepatoCellular Carcinoma. | Day 0 |
| Number of cfDNA amount with the Barcelona Clinic of Liver Cancer (BCLC) stage of HepatoCellular Carcinoma. | Day 0 |
| ID | Term |
|---|---|
| D006528 | Carcinoma, Hepatocellular |
| ID | Term |
|---|---|
| D000230 | Adenocarcinoma |
| D002277 | Carcinoma |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D008113 | Liver Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D004066 | Digestive System Diseases |
| D008107 | Liver Diseases |
Not provided
Not provided