Method for diagnostics of the origin of infections (bacterial vs viral) based on the identification of activation markers of blood neutrophils and monocytes will be developed.

During the study, method for diagnostics of the origin of infections (bacterial vs viral) based on the identification of activation markers of blood neutrophils and monocytes will be developed.This method will allow to make a diagnosis within an hour after blood sampling.

The expression of the following markers of activation will be studied using flow cytometry: CD11b, CD11c, CD13, CD16, CD32, CD35, CD38, CD62L, CD64, CD66b, CD88, CD284, HLA-ABC and HLA-DR.

Inclusion Criteria:

• neuroinfections or acute intestinal infections;
• the possibility of blood sampling within a period of up to 24 hours from the moment of admission to hospital;
• less than 72 hours passed after the onset of the disease and until blood was collected;

Exclusion Criteria:

• refuse of patient to participate in the trial;
• more than 24 hours passed after the patient entered the hospital;
• the disease began more than 72 hours ago;
• concomitant severe acute and chronic diseases;
• malignant neoplasms, treatment at a time of less than 1 year, autoimmune diseases in the phase of exacerbation;
• pregnancy/lactation;
• HIV, Hepatites B/C;
• active tuberculosis;
• alcohol use disorder/drug addiction.

Patients admitted to the infectious departments of city hospitals.